Evidence map›Paper›PMID 38733712›Full record

ArticleHearing research2024

Neural processing in the primary auditory cortex following cholinergic lesions of the basal forebrain in ferrets.

Fernando R Nodal, Nicholas D Leach, Peter Keating, Johannes C Dahmen, Dylan Zhao, Andrew J King, Victoria M Bajo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hearing research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fernando R NodalDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom. Electronic address: fernando.nodal@dpag.ox.ac.uk.
Nicholas D LeachRed Thread Market Access. United Kingdom.
Peter KeatingUCL Ear Institute, 332 Gray's Inn Road, London WC1X 8EE, United Kingdom.
Johannes C DahmenDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.
Dylan ZhaoDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.
Andrew J KingDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.
Victoria M BajoDepartment of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford OX1 3PT, United Kingdom.

Funding

Wellcome TrustWellcome Trust WT108369/Z/2015/Z
6 · The paper itself

Abstract

Cortical acetylcholine (ACh) release has been linked to various cognitive functions, including perceptual learning. We have previously shown that cortical cholinergic innervation is necessary for accurate sound localization in ferrets, as well as for their ability to adapt with training to altered spatial cues. To explore whether these behavioral deficits are associated with changes in the response properties of cortical neurons, we recorded neural activity in the primary auditory cortex (A1) of anesthetized ferrets in which cholinergic inputs had been reduced by making bilateral injections of the immunotoxin ME20.4-SAP in the nucleus basalis (NB) prior to training the animals. The pattern of spontaneous activity of A1 units recorded in the ferrets with cholinergic lesions (NB ACh

Indexed as

Acoustic StimulationAuditory CortexBasal ForebrainFerretsAcetylcholineAdaptation, PhysiologicalAnimalsAuditory PathwaysAuditory ThresholdBasal Nucleus of MeynertBehavior, AnimalCholinergic NeuronsFemaleImmunotoxinsMaleNeuronsAcetylcholineImmunotoxinsAcetylcholineAuditory cortexMonaural occlusionNucleus basalisSpectral sensitivityVirtual acoustic space

Identifiers

PMID38733712
PMCPMC11265294

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.