ArticleCell reports2024
IL-22 promotes mucin-type O-glycosylation and MATH1
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Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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14citing papers in PubMed
–field-weighted citation impact
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Who cites it
14 citing papers in PubMed.
- Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1-FOXO1 Signaling to Enhance ILC3s Effector Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Urolithin A activates aryl hydrocarbon receptor-NLRP6-mediated pathways in intestinal epithelial cells to modulate mucosal immunity and strengthen gut barrier integrity.Nature communications · 2026Article
- Distinct O-Linked Glycosylation Systems in Signaling and Immune Regulation.International journal of molecular sciences · 2026Review
- Intestinal T cells in aging: implications for gut barrier integrity and inflammaging.GeroScience · 2026Review
- High altitude-mediated immune remodeling accelerates aging.Science advances · 2026Article
- Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling.International dental journal · 2026Article
- The Intestinal Barrier: A Multilayered Gatekeeper Against Systemic Disease.International journal of microbiology · 2026Review
- Constructing a Prognostic Model for Clear Cell Renal Cell Carcinoma Based on Glycosyltransferase Gene and Verification of Key Gene Identification.International journal of molecular sciences · 2025Article
- A glycan atlas of the mammalian intestine through ontogeny and inflammation.bioRxiv : the preprint server for biology · 2025Article
- Association between gut microbiota in HIV-infected patients and immune reconstitution following antiretroviral therapy (ART).BMC infectious diseases · 2025Article
- Transcriptome analysis reveals modulations in glycosylation profiles of the mucosal barrier and their potential interaction with gut microbiota in weaned piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations.Journal of inflammation research · 2025Article
- Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells.Cellular & molecular immunology · 2024Review
- Involvement of Intestinal Epithelium Aryl Hydrocarbon Receptor Expression and 3, 3'-Diindolylmethane in Colonic Tertiary Lymphoid Tissue Formation.International journal of molecular sciences · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors.
Ankita SinghDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Michael BeaupreDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Cecilia Villegas-NovoaDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Kiyoshi ShiomitsuDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Stephen J GaudinoDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Suzanne TawchDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Ruhee DamleDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Cody KempenDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Biswa ChoudhuryGlycoAnalytics Core, University of California, San Diego, La Jolla, CA 92093, USA.
Jeremy P McAleerDepartment of Pharmaceutical Sciences, Marshall University School of Pharmacy, Huntington, WV 25701, USA.
Brian S SheridanDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Paula DenoyaDivision of Colon and Rectal Surgery, Department of Surgery, Stony Brook University Hospital, Stony Brook, NY 11794, USA.
Richard S BlumbergDivision of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Patrick HearingDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.
Nancy L AllbrittonDepartment of Bioengineering, University of Washington, Seattle, WA 98195, USA.
Pawan KumarDepartment of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA. Electronic address: pawan.kumar@stonybrook.edu.
Funding
Endoplasmic reticulum stress and intestinal inflammationR01DK088199 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI Richard S Blumberg · 2010 to 2026
$9.6MRegulation of Nuclear Signaling Pathways by the Adenovirus E4-ORF3 ProteinR01CA122677 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI HEARING, PATRICK · 2007 to 2022
$5.2MDevelopment of a microphysiologic system to assay the interaction of the human colonic epithelium on Clostridium difficileR01DK120606 · NIDDK · UNIVERSITY OF WASHINGTON · PI ALLBRITTON, NANCY L., SHEIKH, SHEHZAD Z. · 2020 to 2023
$2.2MIntestinal IL-17RA signaling and mucosal host defenseR01DK121798 · NIDDK · STATE UNIVERSITY NEW YORK STONY BROOK · PI KUMAR, PAWAN · 2019 to 2023
$2.1MInvestigating the role of Akkermansia muciniphila and intestinal IL-17RA signaling in autoimmune inflammationR21AI146696 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KUMAR, PAWAN · 2019 to 2020
$432kPaneth cell-specific IL-22Ra1 signaling in mucosal host defenseR21AI149257 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KUMAR, PAWAN · 2020 to 2021
$432kNCI NIH HHS R01 CA122677NIAID NIH HHS R21 AI146696NIAID NIH HHS R21 AI149257NIDDK NIH HHS R01 DK088199NIDDK NIH HHS R01 DK120606NIDDK NIH HHS R01 DK121798
Abstract
The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of intestinal epithelial cell (IEC). By using a range of IEC type-specific Il22Ra1 conditional knockout mice and a dextran sulfate sodium (DSS) colitis model, we demonstrate that IL-22Ra1 signaling in MATH1
Indexed as
ColitisGlycosylationInterleukin-22InterleukinsReceptors, InterleukinAnimalsBasic Helix-Loop-Helix ProteinsDextran SulfateGalactosyltransferasesHumansInflammationIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutMucinsAtoh1 protein, mouseBasic Helix-Loop-Helix ProteinsDextran SulfateGalactosyltransferasesIL22 protein, humanInterleukin-22interleukin-22, mouseinterleukin-22 receptorInterleukinsMucinsReceptors, InterleukinB3GALT5colitisCP: ImmunologyepitheliumIL-22IL-22Ra1MATH1mucinO-glycanregenerationSTAT3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.