Evidence map›Paper›PMID 38733503›Full record

ArticleCell biochemistry and biophysics2024

Knocking Down PIAS3 Reduces H

Baixue Wang, Wenxin Qian, Kaiyue Chen, Meng Li, Caiping Du

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biochemistry and biophysics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Baixue WangResearch Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Wenxin QianResearch Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Kaiyue ChenResearch Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China.
Meng LiResearch Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. limeng@xzhmu.edu.cn.
Caiping DuResearch Center for Biochemistry and Molecular Biology, Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. caipingdu@xzhmu.edu.cn.

Funding

National Natural Science Foundation of China 32100769National Natural Science Foundation of China 81100852Natural Science Foundation of the Jiangsu Higher Education Institutions 20KJA310010Xuzhou Medical University D2020054
6 · The paper itself

Abstract

Oxidative stress is involved in the pathological processes of many neurodegenerative diseases. Protein modification by small ubiquitin-like modifiers (SUMOs) has been implicated in oxidative stress injury. By conjugating SUMOs to their selective protein substrates, SUMO ligases play critical roles in regulating functions of proteins involved in oxidative stress injury. In this study, we screened siRNAs to knockdown the SUMO ligase PIAS3 to assess its role in H

Indexed as

ApoptosisHydrogen PeroxideOxidative Stressp38 Mitogen-Activated Protein KinasesProtein Inhibitors of Activated STATSumoylationAnimalsCaspase 3Cell LineCell SurvivalGene Knockdown TechniquesJNK Mitogen-Activated Protein KinasesMiceMolecular ChaperonesReactive Oxygen SpeciesRNA InterferenceCaspase 3Hydrogen PeroxideJNK Mitogen-Activated Protein KinasesMolecular Chaperonesp38 Mitogen-Activated Protein KinasesPias3 protein, mouseProtein Inhibitors of Activated STATReactive Oxygen SpeciesRNA, Small InterferingCell apoptosisOxidative stressPIAS3ROSSUMOylation

Identifiers

PMID38733503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.