Evidence map›Paper›PMID 38733502›Full record

ArticleInternational urology and nephrology2024

Parameters affecting the success rate of microscopic testicular sperm extraction in male patients with a solitary testis and non-obstructive azoospermia.

Eray Hasirci, Erman Ceyhan, Mehmet Hamza Gultekin, Mehmet Vehbi Kayra, Yalcin Kizilkan, Omer Yildirim, Mesut Altan, Iyimser Ure, Tufan Cicek, Cem Sah and 3 more

Abstract readMulticenter StudyComparative Study
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In one paragraph

Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Eray HasirciFaculty of Medicine, Department of Urology, Baskent University, Ankara, Turkey. ehasirci@baskent.edu.tr.
Erman CeyhanFaculty of Medicine, Department of Urology, Baskent University, Ankara, Turkey.
Mehmet Hamza GultekinCerrahpasa Faculty of Medicine, Department of Urology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Mehmet Vehbi KayraFaculty of Medicine, Department of Urology, Baskent University, Adana, Turkey.
Yalcin KizilkanDepartment of Urology, Ankara Bilkent City Hospital, Ankara, Turkey.
Omer YildirimGelibolu Sehit Koray Onay State Hospital, Urology Clinic, Canakkale, Turkey.
Mesut AltanFaculty of Medicine, Department of Urology, Hacettepe University, Ankara, Turkey.
Iyimser UreFaculty of Medicine, Department of Urology, Eskisehir Osmangazi University, Eskisehir, Turkey.
Tufan CicekEtlik Zubeyde Hanim Maternity and Women's Health Teaching and Research Hospital, Ankara, Turkey.
Cem SahMedline Hospital, Adana, Turkey.
Caner IncekasFaculty of Medicine, Department of Biostatistics, Baskent University, Ankara, Turkey.
Umit GulDepartment of Urology, Private EPC Hospital, Adana, Turkey.
Tahsin TuruncUroCentre Urology Clinic, Adana, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed to compare the success rate of spermatozoa retrieval through microscopic testicular sperm extraction (mTESE) in non-obstructive azoospermic (NOA) men with a solitary testis with that of mTESE in NOA men with bilateral testes and the parameters affecting these rates.

methodsA retrospective cross-sectional study of factors contributing to infertility in NOA patients with a solitary testis and men with bilateral testes was carried out. In this multicenter study, 74 patients with NOA with a solitary testis were matched with 74 patients with bilateral testes in terms of age, duration of infertility, and volume of the solitary testis from 2770 patients with NOA with bilateral testes. Hormonal parameters, presence of varicocele, history of varicocelectomy, history of undescended testis and karyotype analysis results were compared.

resultsSpermatozoa were obtained from 40 (54.1%) patients with a solitary testis and 42 (56.76%) patients with bilateral testes. No differences were found regarding age, duration of infertility, or mean testicular volume between patients with a solitary testis and patients with bilateral testes. When serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels were compared regardless of sperm retrieval status, it was observed that both levels were greater in the group of patients with a solitary testis (p < 0.01). Patients with solitary and bilateral testes from whom spermatozoa were obtained had larger testes than those from whom spermatozoa could not be obtained (p < 0.05). Similarly, the serum levels of FSH and LH were significantly greater in patients with a solitary testis than in those with bilateral testes (p < 0.05).

conclusionsTo the best of our knowledge, this is the first study in the literature to evaluate the parameters that influence mTESE outcome in NOA patients with a solitary testis and NOA patients with bilateral testes. Greater testicular volume was found to positively affect spermatozoa retrieval for patients with a solitary testis. The higher levels of FSH and LH in patients with a solitary testis than in patients with bilateral testes of similar testicular volume may be due to a compensatory mechanism developed by the hypothalamic-pituitary-gonadal axis. The fact that these hormones are higher in patients with a solitary testis does not mean that the number of spermatozoa obtained through mTESE will be decreased.

Indexed as

AzoospermiaFollicle Stimulating HormoneLuteinizing HormoneSperm RetrievalTestisAdultCross-Sectional StudiesHumansMaleMicrosurgeryRetrospective StudiesTreatment OutcomeFollicle Stimulating HormoneLuteinizing HormoneMicro TESENon-obstructive azoospermiaSolitary testisSperm retriveal

Identifiers

PMID38733502

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