ArticleMagma (New York, N.Y.)2024
A straightforward procedure to build a non-toxic relaxometry phantom with desired T1 and T2 times at 3T.
Article in Magma (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Bi-component modeling of cerebrospinal fluid outflow using Time-SLIP MRI.Fluids and barriers of the CNS · 2026Article
- Recipe for Hydrogels With Tunable Relaxation and Diffusion Properties for Use as MRI Test Materials.Magnetic resonance in medicine · 2026Article
- The dynamic course of spontaneous muscular contractions assessed using multiple-point acquisition in diffusion-weighted stimulated echo imaging.Magnetic resonance in medicine · 2026Article
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5 authors.
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Abstract
objectiveTo prepare and analyze soy-lecithin-agar gels for non-toxic relaxometry phantoms with tissue-like relaxation times at 3T.
methodsPhantoms mimicking the relaxation times of various tissues (gray and white matter, kidney cortex and medulla, spleen, muscle, liver) were built and tested with a clinical 3T whole-body MR scanner. Simple equations were derived to calculate the appropriate concentrations of soy lecithin and agar in aqueous solutions to achieve the desired relaxation times. Phantoms were tested for correspondence between measurements and calculated T1 and T2 values, reproducibility, spatial homogeneity, and temporal stability. T1 and T2 mapping techniques and a 3D T1-weighted sequence with high spatial resolution were applied.
resultsExcept for the liver relaxation phantom, all phantoms were successfully and reproducibly produced. Good agreement was found between the targeted and measured relaxation times. The percentage deviations from the targeted relaxation times were less than 3% for T1 and less than 6.5% for T2. In addition, the phantoms were homogeneous and had little to no air bubbles. However, the phantoms were unstable over time: after a storage period of 4 weeks, mold growth and also changes in relaxation times were detected in almost all phantoms.
conclusionSoy-lecithin-agar gels are a non-toxic material for the construction of relaxometry phantoms with tissue-like relaxation times. They are easy to prepare, inexpensive and allow independent adjustment of T1 and T2. However, there is still work to be done to improve the long-term stability of the phantoms.
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