Comparative Molecular and Biological Characteristic of the Systemic Inflammatory Response in Adult and Old Male Wistar Rats with Different Resistance to Hypoxia.

D Sh Dzhalilova, M V Silina, A M Kosyreva, I S Tsvetkov, O V Makarova

Abstract readComparative Study

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

D Sh DzhalilovaA. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia. juliajal93@mail.ru.

M V SilinaA. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.

A M KosyrevaA. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.

I S TsvetkovA. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.

O V MakarovaA. P. Avtsyn Research Institute of Human Morphology, A. P. Petrovsky Russian Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Morphological, molecular, and biological features of the systemic inflammatory response induced by LPS administration were assessed in adult and old male Wistar rats with high and low resistance to hypoxia. In 6 h after LPS administration, mRNA expression levels of Hif1a, Vegf, Nfkb, and level of IL-1β protein in old rats were higher than in adult rats regardless of hypoxia tolerance. The morphometric study showed that the number of neutrophils in the interalveolar septa of the lungs was significantly higher in low-resistant adult and old rats 6 h after LPS administration. Thus, in old male Wistar rats, systemic inflammatory response is more pronounced than in adult rats and depends on the initial tolerance to hypoxia, which should be considered when developing new approaches to the therapy of systemic inflammatory response in individuals of different ages.

Indexed as

HypoxiaHypoxia-Inducible Factor 1, alpha SubunitInterleukin-1betaRats, WistarAge FactorsAnimalsInflammationLipopolysaccharidesLungMaleNeutrophilsNF-kappa BRatsRNA, MessengerVascular Endothelial Growth Factor AHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitIL1B protein, ratInterleukin-1betaLipopolysaccharidesNF-kappa BRNA, MessengerVascular Endothelial Growth Factor Aageinflammationratstolerance to hypoxia

Identifiers

PMID38733478

DOI10.1371/journal.ppat.1004651

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