Trial reportClinical oral investigations2024
Resin infiltration versus fluoride varnish for visual improvement of white spot lesions during multibracket treatment. A randomized-controlled clinical trial.
Trial report in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Outcomes of resin infiltration for white spot lesions at different time points: a systematic review and meta-analysis.European journal of orthodontics · 2026Pooled it
- Effect of Self-Assembling Peptide on White Spot Lesions in Orthodontic Patients: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2026Pooled it
- Efficacy of various interventions for the management of white spot lesions associated with fixed orthodontic treatment: a systematic review and network meta-analysis of randomized controlled trials.BMC oral health · 2026Pooled it
- Comparative assessment of four treatments for post orthodontic white spot lesions over a 24-month period: a randomized controlled clinical trial.BMC oral health · 2026Trial
- Esthetic Rehabilitation of Anterior Teeth With Diastemas and MIH-Related Enamel Opacities.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026Article
- Awareness and perception of white spot lesions amongst adolescents undergoing orthodontic treatment with fixed appliances: a cross-sectional study of caries preventive adherence.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Shear Bond Strength of Orthodontic Brackets on Demineralized Enamel Before and After Application of a Resin Infiltrant Remineralizing Agent: An In Vitro Study.Dentistry journal · 2026Article
- Review
- Resin infiltration and fluoride varnish for caries control in children: A systematic review.Bioinformation · 2025Article
- Iatrogenic Enamel Lesions with Fixed Multi-bracket Treatment.Journal of pharmacy & bioallied sciences · 2024Article
- Management of white spot enamel lesions with resin infiltration: potentials and future research directions.Evidence-based dentistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThis study aimed to evaluate the visual improvement of resin infiltration of white spot lesions (WSL) during orthodontic treatment with the multibracket appliance (MBA) compared to fluoride varnish.
methodsPatients aged 12-17 years with at least one WSL with an International Caries Detection and Assessment System (ICDAS) score of 1-2 during an active MBA treatment were included and randomized to receive either resin infiltration (Icon) or fluoride application (Flairesse). Standardized digital images were obtained before, one-day, one-week, one-month, three-months and six-months after treatment using a DSLR camera and a matching polarization filter. A grey reference card was used for color standardization. A Matlab routine was used to measure the color difference between adjacent healthy enamel and treated WSL. The independent-samples t-test was used for intergroup and paired-samples t-test for intragroup comparison.
resultsImages of 116 teeth from 36 patients were analyzed. The ΔE for the "Icon" treated WSL was smaller (T1
conclusionWSL infiltration management during orthodontic treatment was superior to topical fluoridation in not only arresting the enamel lesions but also significantly improving the aesthetic appearance of demineralized regions around the brackets. CLINICAL RELEVANCE: WSL treatment in orthodontic patients is usually initiated after debonding. Research has shown that the earlier WSL is treated, the better the aesthetic outcome. There is limited data on the efficacy of resin infiltration of WSL during orthodontic treatment.
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