Evidence map›Paper›PMID 38733105›Full record

ArticleSynapse (New York, N.Y.)2024

Time of day does not impact spinal serotonin levels in humans.

Sharath Kumar Anand, Raj S Lavadi, Benjamin R Johnston, Joshua I Chalif, James M Scanlon, Weiwen Wang, Nitin Agarwal, David K Hamilton, Clinton W Van't Land, Daryl P Fields

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Synapse (New York, N.Y.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sharath Kumar AnandDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Raj S LavadiDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Benjamin R JohnstonDepartment of Neurological Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Joshua I ChalifDepartment of Neurological Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
James M ScanlonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Weiwen WangDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nitin AgarwalDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
David K HamiltonDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Clinton W Van't LandDepartment of Pediatrics and Metabolic Core Facility, University of Pittsburgh.
Daryl P FieldsDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4594-2996

Funding

TRAINING IN TRAUMA AND SEPSIS RESEARCHT32GM008516 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TIMOTHY R BILLIAR · 1994 to 2026
$9.4M
CSF 5-HIAA detects secondary hypoxic insults in humans with traumatic spinal cord injuriesR00GM159353 · NIGMS · UNIVERSITY OF FLORIDA · PI Daryl Fields · 2025 to 2026
$498k
Cerebral spinal fluid serotonin and adenosine levels detect secondary injuries in traumatic spinal cord injury patientsK99GM159353 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FIELDS, DARYL · 2024 to 2024
$111k
Chuck Noll Foundation for Brain Injury ResearchNIGMS NIH HHS K99 GM159353NIGMS NIH HHS R00 GM159353
6 · The paper itself

Abstract

Spinal serotonin enables neuro-motor recovery (i.e., plasticity) in patients with debilitating paralysis. While there exists time of day fluctuations in serotonin-dependent spinal plasticity, it is unknown, in humans, whether this is due to dynamic changes in spinal serotonin levels or downstream signaling processes. The primary objective of this study was to determine if time of day variations in spinal serotonin levels exists in humans. To assess this, intrathecal drains were placed in seven adults with cerebrospinal fluid (CSF) collected at diurnal (05:00 to 07:00) and nocturnal (17:00 to 19:00) intervals. High performance liquid chromatography with mass spectrometry was used to quantify CSF serotonin levels with comparisons being made using univariate analysis. From the 7 adult patients, 21 distinct CSF samples were collected: 9 during the diurnal interval and 12 during nocturnal. Diurnal CSF samples demonstrated an average serotonin level of 216.6

Indexed as

Circadian RhythmSerotoninAdultAgedChromatography, High Pressure LiquidFemaleHumansMaleMiddle AgedSpinal CordSerotonin5‐HIAAcircadianday timenight timeserotonin

Identifiers

PMID38733105
PMCPMC13032765

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.