Evidence map›Paper›PMID 38732582›Full record

ArticleNutrients2024

Targeting Non-Alcoholic Fatty Liver Disease with Hawthorn Ethanol Extract (HEE): A Comprehensive Examination of Hepatic Lipid Reduction and Gut Microbiota Modulation.

Tianyu Wang, Dawei Wang, Yinghui Ding, He Xu, Yue Sun, Jumin Hou, Yanrong Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tianyu WangCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.
Dawei WangSchool of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.
Yinghui DingCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.
He XuCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.
Yue SunCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.
Jumin HouCollege of Food Science and Engineering, Changchun University, Changchun 130022, China.
Yanrong ZhangSchool of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, China.

Funding

Science and Technology Development Project Foudation of Jilin Province 20210203179SFScience and Technology Projects of Jilin Provincial Department of Education JJKH20210617KJ
6 · The paper itself

Abstract

Recent studies have highlighted the lipid-lowering ability of hawthorn ethanol extract (HEE) and the role played by gut flora in the efficacy of HEE. Our study sought to explore the effects of HEE on non-alcoholic fatty liver disease (NAFLD) in normal flora and pseudo germ-free mice. The results showed that HEE effectively diminished hepatic lipid accumulation, ameliorated liver function, reduced inflammatory cytokine levels and blood lipid profiles, and regulated blood glucose levels. HEE facilitated triglyceride breakdown, suppressed fatty acid synthesis, and enhanced intestinal health by modulating the diversity of the gut microbiota and the production of short-chain fatty acids in the gut. In addition, HEE apparently helps to increase the presence of beneficial genera of bacteria, thereby influencing the composition of the gut microbiota, and the absence of gut flora affects the efficacy of HEE. These findings reveal the potential of hawthorn for the prevention and treatment of NAFLD and provide new perspectives on the study of functional plants to improve liver health.

Indexed as

CrataegusGastrointestinal MicrobiomeLipid MetabolismLiverNon-alcoholic Fatty Liver DiseasePlant ExtractsAnimalsCytokinesDisease Models, AnimalEthanolFatty Acids, VolatileMaleMiceMice, Inbred C57BLTriglyceridesCytokinesEthanolFatty Acids, VolatilePlant ExtractsTriglyceridesgut microbiotahawthorn ethanol extracthigh-fat dietnonalcoholic fatty liver diseaseshort-chain fatty acids

Identifiers

PMID38732582
PMCPMC11085873

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.