Evidence map›Paper›PMID 38732550›Full record

ArticleNutrients2024

Neonatal Vitamin D and Associations with Longitudinal Changes of Eczema up to 25 Years of Age.

Rong Zeng, Caroline J Lodge, Jennifer J Koplin, Diego J Lopez, Bircan Erbas, Michael J Abramson, Darryl Eyles, Anne-Louise Ponsonby, Matthias Wjst, Katrina Allen and 2 more

Abstract read
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In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rong ZengAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.ORCID 0000-0003-0192-4072
Caroline J LodgeAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.
Jennifer J KoplinMurdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
Diego J LopezAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.ORCID 0000-0001-5911-3980
Bircan ErbasSchool of Psychology and Public Health, La Trobe University, Melbourne, VIC 3086, Australia.
Michael J AbramsonSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.ORCID 0000-0002-9954-0538
Darryl EylesQueensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia.
Anne-Louise PonsonbyMurdoch Children's Research Institute, Melbourne, VIC 3052, Australia.ORCID 0000-0002-6581-3657
Matthias WjstInstitut für Medizinische Informatik, Statistik und Epidemiologie, Technische Universität München, 80333 München, Germany.
Katrina AllenMurdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
Shyamali C DharmageAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.ORCID 0000-0001-6063-1937
Adrian J LoweAllergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC 3052, Australia.ORCID 0000-0002-4691-8162

Funding

National Health and Medical Research Council 1047485
6 · The paper itself

Abstract

backgroundEarly-life vitamin D is a potentially modifiable risk factor for the development of eczema, but there is a lack of data on longitudinal associations.

methodWe measured 25(OH)D3 levels from neonatal dried blood spots in 223 high-allergy-risk children. Latent class analysis was used to define longitudinal eczema phenotype up to 25 years (4 subclasses). Skin prick tests (SPTs) to 6 allergens and eczema outcomes at 6 time points were used to define eczema/sensitization phenotypes. Associations between 25(OH)D3 and prevalent eczema and eczema phenotypes were assessed using logistic regression models.

resultsMedian 25(OH)D3 level was 32.5 nmol/L (P25-P75 = 23.1 nmol/L). Each 10 nmol/L increase in neonatal 25(OH)D3 was associated with a 26% reduced odds of early-onset persistent eczema (adjusted multinomial odds ratio (aMOR) = 0.74, 95% CI = 0.56-0.98) and 30% increased odds of early-onset-resolving eczema (aMOR = 1.30, 95% CI = 1.05-1.62) when compared to minimal/no eczema up to 12 years. Similar associations were seen for eczema phenotype up to 25 years. We did not see any strong evidence for the association between neonatal 25(OH)D3 and prevalent eczema or eczema/sensitization phenotype.

conclusionsHigher neonatal 25(OH)D3 levels, a reflection of maternal vitamin D levels in pregnancy, may reduce the risk of early-onset persistent eczema.

Indexed as

EczemaVitamin DAdolescentAdultCalcifediolChildChild, PreschoolFemaleHumansInfantInfant, NewbornLongitudinal StudiesMalePhenotypePrevalenceRisk FactorsCalcifediolVitamin D25-hydroxyvitamin Ddried whole blood spotseczema phenotyperisk factorssensitization

Identifiers

PMID38732550
PMCPMC11085504

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.