Evidence map›Paper›PMID 38732315›Full record

ArticleDiagnostics (Basel, Switzerland)2024

Analysis of Choriocapillaris Reperfusion Topography following Faricimab Treatment for Neovascular Age-Related Macular Degeneration in Non-Treatment-Naïve Patients.

Max Brinkmann, Pasquale Viggiano, Giacomo Boscia, Mathis Danckwardt, Evelyn Susantija, Tom Müller, Niccolò Castellino, Jakob Schweighofer, Francesco Boscia, Mario Damiano Toro and 1 more

Abstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Max BrinkmannDepartment of Ophthalmology, Klinikum Klagenfurt, 9020 Klagenfurt, Austria.
Pasquale ViggianoDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-0323-967X
Giacomo BosciaDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", 70121 Bari, Italy.ORCID 0000-0002-8768-899X
Mathis DanckwardtDepartment of Ophthalmology, Universitätsklinikum Schleswig-Holstein, 23564 Lübeck, Germany.
Evelyn SusantijaDepartment of Ophthalmology, Universitätsklinikum Schleswig-Holstein, 23564 Lübeck, Germany.
Tom MüllerDepartment of Ophthalmology, Klinikum Klagenfurt, 9020 Klagenfurt, Austria.ORCID 0009-0009-9204-4898
Niccolò CastellinoDepartment of Ophthalmology, University of Catania, 95123 Catania, Italy.
Jakob SchweighoferDepartment of Ophthalmology and Optometry, Medical University of Vienna, 1090 Vienna, Austria.
Francesco BosciaDepartment of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", 70121 Bari, Italy.
Mario Damiano ToroEye Clinic, Public Health Department, University of Naples Federico II, 80133 Naples, Italy.
Yosuf El-ShabrawiDepartment of Ophthalmology, Klinikum Klagenfurt, 9020 Klagenfurt, Austria.ORCID 0000-0003-1704-0183

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assess changes in choriocapillaris (CC) vascular density surrounding macular neovascularization (MNV) in age-related macular degeneration (AMD) when transitioning from various anti-VEGF treatments to faricimab, using optical coherence tomography angiography (OCTA). 25 eyes of 22 individuals who underwent intravitreal faricimab injections for neovascular AMD with type 1 MNV were included. OCTA images were obtained prior to (T0), after one (T1), and after three faricimab injections (T2); Noteworthy changes occurred in the first ring at T2 in comparison to T0. The percentage of CC flow deficit (FD%), FD average area (FDa), and FD number (FDn) in 5 rings (R1-R5) surrounding the dark halo around the MNV were calculated. A reduction in FD% at T2 compared to T0 (50.5 ± 10.2% at T0, 46.4 ± 10.6% at T2;

Indexed as

AMDangiopoietin 2anti-VEGFchoroidfaricimabOCTA

Identifiers

PMID38732315
PMCPMC11083352

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.