Evidence map›Paper›PMID 38732165›Full record

ArticleInternational journal of molecular sciences2024

Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population.

Tyrel Porter, Miguel Mayol Del Valle, Lilia Kucheryavykh

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tyrel PorterDepartment of Biochemistry, Universidad Central del Caribe, Bayamón, PR 00956, USA.ORCID 0009-0003-1413-2100
Miguel Mayol Del ValleDepartment of Surgery, Neurosurgery Section, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00921, USA.ORCID 0000-0002-3269-3994
Lilia KucheryavykhDepartment of Biochemistry, Universidad Central del Caribe, Bayamón, PR 00956, USA.ORCID 0000-0001-8053-5619

Funding

Pyk2 regulates extracellular vesicles release in GBM cells and modulates activation of tumor infiltrating myeloid cellsR15CA287203 · NCI · UNIVERSIDAD CENTRAL DEL CARIBE · PI KUCHERYAVYKH, LILIA · 2024 to 2024
$382k
NCI NIH HHS R15 CA287203NIH HHS 1R15CA287203
6 · The paper itself

Abstract

Glioblastoma (GBM), an aggressive form of brain cancer, has a higher incidence in non-Hispanics when compared to the US Hispanic population. Using data from RT-PCR analysis of 21 GBM tissue from Hispanic patients in Puerto Rico, we identified significant correlations in the gene expression of focal adhesion kinase and proline-rich tyrosine kinase (PTK2 and PTK2B) with NGFR (nerve growth factor receptor), PDGFRB (platelet-derived growth factor receptor B), EGFR (epithelial growth factor receptor), and CXCR1 (C-X-C motif chemokine receptor 1). This study further explores these correlations found in gene expression while accounting for sex and ethnicity. Statistically significant (

Indexed as

Brain NeoplasmsGene Expression Regulation, NeoplasticGlioblastomaHispanic or LatinoSignal TransductionAdultAgedErbB ReceptorsFemaleFocal Adhesion Kinase 1Focal Adhesion Kinase 2Focal Adhesion Protein-Tyrosine KinasesHumansMaleMiddle AgedNerve Tissue ProteinsEGFR protein, humanErbB ReceptorsFocal Adhesion Kinase 1Focal Adhesion Kinase 2Focal Adhesion Protein-Tyrosine KinasesNerve Tissue ProteinsNGFR protein, humanPDGFRB protein, humanPTK2B protein, humanPTK2 protein, humanReceptor, Platelet-Derived Growth Factor betaReceptors, Nerve Growth Factorethnicitygene expressionglioblastoma

Identifiers

PMID38732165
PMCPMC11084467

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.