Evidence map›Paper›PMID 38732162›Full record

ArticleInternational journal of molecular sciences2024

Positron Emission Tomography with [

Evan Gallagher, Catherine Hou, Yi Zhu, Chia-Ju Hsieh, Hsiaoju Lee, Shihong Li, Kuiying Xu, Patrick Henderson, Rea Chroneos, Malkah Sheldon and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. PET Imaging with [Antioxidants (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Evan GallagherDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.ORCID 0000-0003-1548-4960
Catherine HouDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8905-8492
Yi ZhuDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Chia-Ju HsiehDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2833-7727
Hsiaoju LeeDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Shihong LiDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kuiying XuDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Patrick HendersonDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Rea ChroneosDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Malkah SheldonDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Shaipreeah RileyDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Kelvin C LukDepartment of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert H MachDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7645-2869
Meagan J McManusDepartment of Anesthesia and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Funding

Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI JOEL Synes PERLMUTTER · 2019 to 2026
$44.1M
Propagation of Lewy pathology in Parkinsons diseaseR01NS088322 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI LUK, KELVIN C · 2015 to 2025
$4.0M
Superoxide-sensitive radiotracer as a predictive biomarker of Parkinson's disease progressionR01NS114656 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI MCMANUS, MEAGAN JOY · 2020 to 2024
$2.6M
Cross-disciplinary training in translational neuroimaging of ADRDT32AG076411 · NIA · UNIVERSITY OF PENNSYLVANIA · PI JOHN A DETRE, MURRAY GROSSMAN · 2022 to 2026
$1.5M
NIA NIH HHS T32 AG076411NIA NIH HHS T32AG076411NIA NIH HHS U19NS110456NINDS NIH HHS R01 NS088322NINDS NIH HHS R01NS088322NINDS NIH HHS R01 NS114656NINDS NIH HHS R01NS114656NINDS NIH HHS U19 NS110456
6 · The paper itself

Abstract

The synucleinopathies are a diverse group of neurodegenerative disorders characterized by the accumulation of aggregated alpha-synuclein (aSyn) in vulnerable populations of brain cells. Oxidative stress is both a cause and a consequence of aSyn aggregation in the synucleinopathies; however, noninvasive methods for detecting oxidative stress in living animals have proven elusive. In this study, we used the reactive oxygen species (ROS)-sensitive positron emission tomography (PET) radiotracer [

Indexed as

alpha-SynucleinBrainDisease Models, AnimalOxidative StressPositron-Emission TomographySynucleinopathiesAnimalsFluorine RadioisotopesMaleMiceMice, TransgenicRadiopharmaceuticalsReactive Oxygen Speciesalpha-SynucleinFluorine RadioisotopesRadiopharmaceuticalsReactive Oxygen SpeciesA53Talpha-synucleinM83oxidative stressParkinson’s diseasePET imagingreactive oxygen speciessynucleinopathy

Identifiers

PMID38732162
PMCPMC11084161

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.