Evidence map›Paper›PMID 38732076›Full record

ReviewInternational journal of molecular sciences2024

Mitochondrial Biomarkers in the Omics Era: A Clinical-Pathophysiological Perspective.

Jacopo Gervasoni, Aniello Primiano, Michela Cicchinelli, Lavinia Santucci, Serenella Servidei, Andrea Urbani, Guido Primiano, Federica Iavarone

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jacopo GervasoniFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.ORCID 0000-0002-3600-392X
Aniello PrimianoFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.ORCID 0000-0001-9415-9175
Michela CicchinelliDepartment of Basic Biotechnological Sciences, Intensive and Perioperative Clinics, Catholic University of Sacred Heart, 00168 Rome, Italy.
Lavinia SantucciFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.ORCID 0000-0002-7448-0604
Serenella ServideiFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.ORCID 0000-0001-8478-2799
Andrea UrbaniFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.
Guido PrimianoFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.ORCID 0000-0001-7616-7008
Federica IavaroneFondazione Policlinico Universitario 'Agostino Gemelli' IRCCS, 00168 Rome, Italy.ORCID 0000-0002-2074-5531

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial diseases (MDs) affect 4300 individuals, with different ages of presentation and manifestation in any organ. How defects in mitochondria can cause such a diverse range of human diseases remains poorly understood. In recent years, several published research articles regarding the metabolic and protein profiles of these neurogenetic disorders have helped shed light on the pathogenetic mechanisms. By investigating different pathways in MDs, often with the aim of identifying disease biomarkers, it is possible to identify molecular processes underlying the disease. In this perspective, omics technologies such as proteomics and metabolomics considered in this review, can support unresolved mitochondrial questions, helping to improve outcomes for patients.

Indexed as

BiomarkersMetabolomicsMitochondriaMitochondrial DiseasesProteomicsAnimalsHumansBiomarkersbiomarkersFTIRLC-MSmetabolomicsmitochondrial diseasespersonalized medicineproteomics

Identifiers

PMID38732076
PMCPMC11084339

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.