Evidence map›Paper›PMID 38732053›Full record

ArticleInternational journal of molecular sciences2024

Early Blood-Brain Barrier Impairment as a Pathological Hallmark in a Novel Model of Closed-Head Concussive Brain Injury (CBI) in Mice.

Stefan J Blaschke, Nora Rautenberg, Heike Endepols, Aileen Jendro, Jens Konrad, Susan Vlachakis, Dirk Wiedermann, Michael Schroeter, Bernd Hoffmann, Rudolf Merkel and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stefan J BlaschkeDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0001-8643-3824
Nora RautenbergDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.
Heike EndepolsInstitute of Radiochemistry and Experimental Molecular Imaging, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0002-6166-4818
Aileen JendroDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.
Jens KonradMechanobiology, Institute of Biological Information Processing (IBI-2), Research Centre Juelich, 52425 Juelich, Germany.
Susan VlachakisDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0002-9429-2475
Dirk WiedermannMultimodal Imaging Group, Max Planck Institute for Metabolism Research, 50931 Cologne, Germany.
Michael SchroeterDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.
Bernd HoffmannMechanobiology, Institute of Biological Information Processing (IBI-2), Research Centre Juelich, 52425 Juelich, Germany.ORCID 0000-0002-3803-8835
Rudolf MerkelMechanobiology, Institute of Biological Information Processing (IBI-2), Research Centre Juelich, 52425 Juelich, Germany.ORCID 0000-0003-3178-3282
Niklas MarklundDepartment of Clinical Sciences Lund, Neurosurgery, Lund University, 221 85 Lund, Sweden.ORCID 0000-0002-9797-5626
Gereon R FinkDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.ORCID 0000-0002-8230-1856
Maria A RuegerDepartment of Neurology, Faculty of Medicine and University Hospital, University of Cologne, 50923 Cologne, Germany.

Funding

Deutsche Forschungsgemeinschaft 431549029-SFB 1451 X01Deutsche Forschungsgemeinschaft FI 773/15-1Marga-und-Walter-Boll Stiftung #210-10-15
6 · The paper itself

Abstract

Concussion, caused by a rotational acceleration/deceleration injury mild enough to avoid structural brain damage, is insufficiently captured in recent preclinical models, hampering the relation of pathophysiological findings on the cellular level to functional and behavioral deficits. We here describe a novel model of unrestrained, single vs. repetitive concussive brain injury (CBI) in male C56Bl/6j mice. Longitudinal behavioral assessments were conducted for up to seven days afterward, alongside the evaluation of structural cerebral integrity by in vivo magnetic resonance imaging (MRI, 9.4 T), and validated ex vivo by histology. Blood-brain barrier (BBB) integrity was analyzed by means of fluorescent dextran- as well as immunoglobulin G (IgG) extravasation, and neuroinflammatory processes were characterized both in vivo by positron emission tomography (PET) using [

Indexed as

Blood-Brain BarrierBrain ConcussionMiceAnimalsBehaviorMalePositron-Emission TomographyRotationblood–brain barriermicemild traumatic brain injuryneuroinflammationPETrepetitive concussion

Identifiers

PMID38732053
PMCPMC11084321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.