Evidence map›Paper›PMID 38732010›Full record

ArticleInternational journal of molecular sciences2024

A Structural In Silico Analysis of the Immunogenicity of L-Asparaginase from

Kellen Cruvinel Rodrigues Andrade, Mauricio Homem-de-Mello, Julia Almeida Motta, Marina Guimarães Borges, Joel Antônio Cordeiro de Abreu, Paula Monteiro de Souza, Adalberto Pessoa, Georgios J Pappas, Pérola de Oliveira Magalhães

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kellen Cruvinel Rodrigues AndradeLaboratory of Natural Products, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Mauricio Homem-de-MelloinSiliTox, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-4541-9177
Julia Almeida MottainSiliTox, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Marina Guimarães BorgesLaboratory of Natural Products, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-8767-407X
Joel Antônio Cordeiro de AbreuLaboratory of Natural Products, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-5969-0806
Paula Monteiro de SouzaLaboratory of Natural Products, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.
Adalberto PessoaDepartment of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-5268-8690
Georgios J PappasDepartment Cell Biology, Institute Biological Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0002-1100-976X
Pérola de Oliveira MagalhãesLaboratory of Natural Products, Department of Pharmacy, Faculty of Health Sciences, University of Brasilia, Brasilia 70910-900, Brazil.ORCID 0000-0001-8011-6940

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Foundation for Research Support of the Federal District 0193.001797/2017Fundação de Amparo à Pesquisa do Estado de São Paulo 193.0000919-2020/07
6 · The paper itself

Abstract

L-asparaginase is an essential drug used to treat acute lymphoid leukemia (ALL), a cancer of high prevalence in children. Several adverse reactions associated with L-asparaginase have been observed, mainly caused by immunogenicity and allergenicity. Some strategies have been adopted, such as searching for new microorganisms that produce the enzyme and applying protein engineering. Therefore, this work aimed to elucidate the molecular structure and predict the immunogenic profile of L-asparaginase from

Indexed as

AsparaginaseComputer SimulationPenicilliumAmino Acid SequenceAspergillusDickeya chrysanthemiEpitopes, B-LymphocyteEpitopes, T-LymphocyteEscherichia coliFungal ProteinsHumansModels, MolecularAsparaginaseEpitopes, B-LymphocyteEpitopes, T-LymphocyteFungal ProteinsALLimmunogenicityL-asparaginasePenicillium cerradense

Identifiers

PMID38732010
PMCPMC11084778

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.