Evidence map›Paper›PMID 38731963›Full record

ArticleInternational journal of molecular sciences2024

Novel Scorpion Toxin ω-Buthitoxin-Hf1a Selectively Inhibits Calcium Influx via Ca

Dan Wang, Volker Herzig, Zoltan Dekan, K Johan Rosengren, Colton D Payne, Md Mahadhi Hasan, Jiajie Zhuang, Emmanuel Bourinet, Lotten Ragnarsson, Paul F Alewood and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dan WangDepartment of Chinese Medicine and Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.ORCID 0000-0002-0185-1347
Volker HerzigCentre for Bioinnovation, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia.ORCID 0000-0003-2514-3983
Zoltan DekanDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
K Johan RosengrenSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-5007-8434
Colton D PayneSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Md Mahadhi HasanPharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh.
Jiajie ZhuangDepartment of Chinese Medicine and Pharmacy, School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Emmanuel BourinetInstitute of Functional Genomics, Montpellier University, CNRS, INSERM, 34090 Montpellier, France.ORCID 0000-0001-8021-0419
Lotten RagnarssonDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-7137-1656
Paul F AlewoodDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-7454-6522
Richard J LewisDivision of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-3470-923X

Funding

Australian Research Council Future Fellowship FT190100482Innovative and Entrepreneurial Program of Jiangsu Province JSSCBS20210960National Health and Medical Research Council APP1072113Senior Talent Foundation of Jiangsu University 20JDG075The Natural Science Foundation of the Jiangsu Higher Education Institutions of China 21KJB350023
6 · The paper itself

Abstract

Venom peptides have evolved to target a wide range of membrane proteins through diverse mechanisms of action and structures, providing promising therapeutic leads for diseases, including pain, epilepsy, and cancer, as well as unique probes of ion channel structure-function. In this work, a high-throughput FLIPR window current screening assay on T-type Ca

Indexed as

Calcium Channels, T-TypeDisease Models, AnimalHyperalgesiaPostoperative PainScorpion VenomsAnimalsCalciumCalcium Channel BlockersHumansMaleMiceCACNA1H protein, humanCacna1h protein, mouseCalciumCalcium Channel BlockersCalcium Channels, T-TypeScorpion Venomsacute post-surgical painperipheral painT-type calcium channelsvenom peptides

Identifiers

PMID38731963
PMCPMC11084959

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.