Evidence map›Paper›PMID 38731942›Full record

ArticleInternational journal of molecular sciences2024

Cytokine CCL9 Mediates Oncogenic KRAS-Induced Pancreatic Acinar-to-Ductal Metaplasia by Promoting Reactive Oxygen Species and Metalloproteinases.

Geou-Yarh Liou, Crystal J Byrd, Peter Storz, Justin K Messex

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Geou-Yarh LiouCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.ORCID 0000-0003-2728-3752
Crystal J ByrdDepartment of Biological Sciences, Clark Atlanta University, Atlanta, GA 30314, USA.
Peter StorzDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.ORCID 0000-0002-0132-5128
Justin K MessexCenter for Cancer Research and Therapeutic Development, Clark Atlanta University, Atlanta, GA 30314, USA.

Funding

To Investigate Molecular Mechanisms of Aging-Related Growth of the Prostate - Implications in Prostate Tumorigenesis and Cancer TreatmentU54MD007590 · NIMHD · CLARK ATLANTA UNIVERSITY · PI JAIDEEP CHAUDHARY · 2019 to 2026
$17.1M
Role of ICAM1 in development and progression of pancreatic cancerR01CA229560 · NCI · MAYO CLINIC JACKSONVILLE · PI STORZ, PETER · 2019 to 2023
$1.8M
Dissecting mechanisms of tumor initiation via immunomodulationSC1GM140907 · NIGMS · CLARK ATLANTA UNIVERSITY · PI LIOU, GEOU-YARH · 2021 to 2024
$1.3M
NCI NIH HHS R01 CA229560NIGMS NIH HHS SC1 GM140907NIGMS NIH HHS SC1GM140907NIMHD NIH HHS U54 MD007590
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) can originate from acinar-to-ductal metaplasia (ADM). Pancreatic acini harboring oncogenic

Indexed as

Acinar CellsCarcinoma, Pancreatic DuctalMetaplasiaPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesAnimalsChemokines, CCHumansMacrophage Inflammatory ProteinsMiceMice, TransgenicPancreasCcl9 protein, mouseChemokines, CCHras protein, mouseKRAS protein, humanMacrophage Inflammatory ProteinsProto-Oncogene Proteins p21(ras)Reactive Oxygen SpeciesADMCCL9KRASG12DMMP14MMP3pancreatic cancerPDAC initiationROS

Identifiers

PMID38731942
PMCPMC11083758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.