Evidence map›Paper›PMID 38731916›Full record

ArticleInternational journal of molecular sciences2024

Design and Synthesis of 1,3-Diarylpyrazoles and Investigation of Their Cytotoxicity and Antiparasitic Profile.

Murat Bozdag, Freke Mertens, An Matheeussen, Natascha Van Pelt, Kenn Foubert, Nina Hermans, Guido R Y De Meyer, Koen Augustyns, Wim Martinet, Guy Caljon and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Murat BozdagLaboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0002-5010-0355
Freke MertensLaboratory of Physiopharmacology, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0002-6091-5291
An MatheeussenLaboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0002-7507-1634
Natascha Van PeltLaboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0001-8922-7903
Kenn FoubertNatural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0003-0661-9579
Nina HermansNatural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0003-3946-7313
Guido R Y De MeyerLaboratory of Physiopharmacology, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0003-3848-8702
Koen AugustynsLaboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.
Wim MartinetLaboratory of Physiopharmacology, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0003-1967-9343
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.ORCID 0000-0002-4870-3202
Pieter Van der VekenLaboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.

Funding

European Cooperation in Science and Technology CA21111Research Foundation - Flanders 1244521NUniversity of Antwerp iBOF-21-053
6 · The paper itself

Abstract

Herein, we report a series of 1,3-diarylpyrazoles that are analogues of compound

Indexed as

PyrazolesTrypanosoma cruziAntiparasitic AgentsAntiprotozoal AgentsDrug DesignHumansLeishmania infantumStructure-Activity RelationshipTrypanosoma brucei rhodesienseAntiparasitic AgentsAntiprotozoal AgentsPyrazoles1,3-diarylpyrazoleantiparasitic activitycytotoxicitypyrazole

Identifiers

PMID38731916
PMCPMC11487390

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.