Evidence map›Paper›PMID 38731914›Full record

ArticleInternational journal of molecular sciences2024

Distinct Driver Pathway Enrichments and a High Prevalence of

Camilo Tapia-Valladares, Guillermo Valenzuela, Evelin González, Ignacio Maureira, Jessica Toro, Matías Freire, Gonzalo Sepúlveda-Hermosilla, Diego Ampuero, Alejandro Blanco, Iván Gallegos and 8 more

Abstract readComparative Study
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Camilo Tapia-ValladaresDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Guillermo ValenzuelaDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Evelin GonzálezCentro de Genética y Genómica, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7610507, Chile.
Ignacio MaureiraDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-8660-2779
Jessica ToroDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-7813-1380
Matías FreireCORFO Center of Excellence in Precision Medicine, Pfizer Chile, Santiago 8380000, Chile.
Gonzalo Sepúlveda-HermosillaCORFO Center of Excellence in Precision Medicine, Pfizer Chile, Santiago 8380000, Chile.
Diego AmpueroCORFO Center of Excellence in Precision Medicine, Pfizer Chile, Santiago 8380000, Chile.
Alejandro BlancoCentro de Genética y Genómica, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7610507, Chile.ORCID 0009-0005-3491-6898
Iván GallegosDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Fernanda MoralesDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
José I EricesDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0003-2898-0541
Olga BarajasDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0002-3013-2106
Mónica AhumadaDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.
Héctor R ContrerasDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0003-4012-2662
Jaime GonzálezDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0003-0324-2948
Ricardo ArmisénCentro de Genética y Genómica, Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clínica Alemana, Universidad del Desarrollo, Santiago 7610507, Chile.ORCID 0000-0003-2567-0521
Katherine MarcelainDepartamento de Oncología Básico Clínico, Facultad de Medicina, Universidad de Chile, Santiago 8380000, Chile.ORCID 0000-0003-4018-6623

Funding

Agencia Nacional de Investigación y Desarrollo ACT210079, FONIS SA20I0059, FONDEF IT16I10051, FONDEF ID21I10355, FONDAP 152220002 (CECAN)CORFO International Center of Excellence Program #13CEE2-21602
6 · The paper itself

Abstract

Colorectal cancer (CRC) is the second leading cause of cancer deaths globally. While ethnic differences in driver gene mutations have been documented, the South American population remains understudied at the genomic level, despite facing a rising burden of CRC. We analyzed tumors of 40 Chilean CRC patients (Chp) using next-generation sequencing and compared them to data from mainly Caucasian cohorts (TCGA and MSK-IMPACT). We identified 388 mutations in 96 out of 135 genes, with

Indexed as

Colonic NeoplasmsMutationTuberous Sclerosis Complex 2 ProteinAdultAgedAged, 80 and overChileFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedSignal TransductionTSC2 protein, humanTuberous Sclerosis Complex 2 ProteinColorectal cancerLATAMNGSprecision medicineTSC2

Identifiers

PMID38731914
PMCPMC11083322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.