Evidence map›Paper›PMID 38731907›Full record

ArticleInternational journal of molecular sciences2024

Maternal Diet High in Linoleic Acid Alters Renal Branching Morphogenesis and mTOR/AKT Signalling Genes in Rat Fetal Kidneys.

Connie McClelland, Olivia J Holland, Nirajan Shrestha, Claire L Jukes, Anna E Brandon, James S M Cuffe, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Connie McClellandSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.
Olivia J HollandSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-5798-5264
Nirajan ShresthaSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0003-1259-0661
Claire L JukesSchool of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
Anna E BrandonSchool of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.
James S M CuffeSchool of Biomedical Sciences, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-2675-8149
Anthony V PerkinsSchool of Pharmacy and Medical Science, Griffith University, Southport, QLD 4222, Australia.ORCID 0000-0002-9829-6772
Andrew J McAinchInstitute for Health and Sport, Victoria University, Melbourne, VIC 3011, Australia.ORCID 0000-0002-8762-4865
Deanne H HryciwWomen's Newborn and Childrens Services, Gold Coast Hospital and Health Service, Southport, QLD 4215, Australia.ORCID 0000-0003-1697-8890

Funding

Allen Foundation 2015
6 · The paper itself

Abstract

Linoleic acid (LA), an n-6 polyunsaturated fatty acid (PUFA), is obtained from the maternal diet during pregnancy, and is essential for normal fetal growth and development. A maternal high-LA (HLA) diet alters maternal and offspring fatty acids, maternal leptin and male/female ratio at embryonic (E) day 20 (E20). We investigated the effects of an HLA diet on embryonic offspring renal branching morphogenesis, leptin signalling, megalin signalling and angiogenesis gene expression. Female Wistar Kyoto rats were fed low-LA (LLA; 1.44% energy from LA) or high-LA (HLA; 6.21% energy from LA) diets during pregnancy and gestation/lactation. Offspring were sacrificed and mRNA from kidneys was analysed by real-time PCR. Maternal HLA decreased the targets involved in branching morphogenesis

Indexed as

KidneyLinoleic AcidMorphogenesisProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesAnimalsFemaleFetusGene Expression Regulation, DevelopmentalMalePregnancyRatsRats, Inbred WKYLinoleic AcidmTOR protein, ratProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinaseskidneylinoleic acidmaternaloffspringsex specific

Identifiers

PMID38731907
PMCPMC11083378

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.