Evidence map›Paper›PMID 38731855›Full record

ArticleInternational journal of molecular sciences2024

Anti-Nociceptive Effects of Sphingomyelinase and Methyl-Beta-Cyclodextrin in the Icilin-Induced Mouse Pain Model.

Ádám Horváth, Anita Steib, Andrea Nehr-Majoros, Boglárka Kántás, Ágnes Király, Márk Racskó, Balázs István Tóth, Eszter Szánti-Pintér, Eva Kudová, Rita Skoda-Földes and 2 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ádám HorváthDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.
Anita SteibDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.
Andrea Nehr-MajorosDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.
Boglárka KántásDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.
Ágnes KirályDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.
Márk RacskóDepartment of Physiology, Faculty of Medicine, University of Debrecen, Nagyerdei Cct. 98., H-4032 Debrecen, Hungary.
Balázs István TóthDepartment of Physiology, Faculty of Medicine, University of Debrecen, Nagyerdei Cct. 98., H-4032 Debrecen, Hungary.ORCID 0000-0002-4103-4333
Eszter Szánti-PintérInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo Namesti 2, 166 10 Prague, Czech Republic.ORCID 0000-0001-8263-9884
Eva KudováInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo Namesti 2, 166 10 Prague, Czech Republic.ORCID 0000-0001-7131-5948
Rita Skoda-FöldesInstitute of Chemistry, Department of Organic Chemistry, University of Pannonia, Egyetem Str. 10., H-8200 Veszprém, Hungary.ORCID 0000-0002-9810-1509
Zsuzsanna HelyesDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.
Éva SzőkeDepartment of Pharmacology and Pharmacotherapy, Medical School, University of Pécs, Szigeti Str. 12., H-7624 Pécs, Hungary.

Funding

Chronic Pain Research Group HUN-REN-PTECzech Academy of Sciences RVO:61388963European Union Next Generation EUMinistry for Innovation and Technology ÚNKP-22-3-I-DE-324National Institute for Research of Metabolic and Cardiovascular Diseases LX22NPO5104National Research, Development and Innovation Fund of Hungary TKP2021-EGA-13National Research, Development and Innovation Fund of Hungary TKP2021-EGA-16National Research, Development and Innovation Office 134725National Research, Development and Innovation Office GINOP-2.3.2-15-2016-00050National Research, Development and Innovation Office NKFIH-138936The National Research, Development and Innovation Office Phar-maLab, RRF-2.3.1-21-2022-00015University of Pecs PTE-ÁOK-KA-2021-09
6 · The paper itself

Abstract

The thermo- and pain-sensitive Transient Receptor Potential Melastatin 3 and 8 (TRPM3 and TRPM8) ion channels are functionally associated in the lipid rafts of the plasma membrane. We have already described that cholesterol and sphingomyelin depletion, or inhibition of sphingolipid biosynthesis decreased the TRPM8 but not the TRPM3 channel opening on cultured sensory neurons. We aimed to test the effects of lipid raft disruptors on channel activation on TRPM3- and TRPM8-expressing HEK293T cells in vitro, as well as their potential analgesic actions in TRPM3 and TRPM8 channel activation involving acute pain models in mice. CHO cell viability was examined after lipid raft disruptor treatments and their effects on channel activation on channel expressing HEK293T cells by measurement of cytoplasmic Ca

Indexed as

beta-CyclodextrinsSphingomyelin PhosphodiesteraseTRPM Cation ChannelsAnalgesicsAnimalsCell SurvivalCHO CellsCholesterolCricetulusDisease Models, AnimalHEK293 CellsHumansMembrane MicrodomainsMicePainPregnenoloneAnalgesicsbeta-CyclodextrinsCholesterolicilinmethyl-beta-cyclodextrinPregnenolonepregnenolone sulfatePyrimidinonesSphingomyelin PhosphodiesteraseTRPM3 protein, mouseTRPM8 protein, mouseTRPM Cation Channelscholesterollipid raftmethyl-beta-cyclodextrinpainsphingomyelinaseTransient Receptor Potential

Identifiers

PMID38731855
PMCPMC11083984

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.