Evidence map›Paper›PMID 38731538›Full record

ArticleMolecules (Basel, Switzerland)2024

Adenosine Encapsulation and Characterization through Layer-by-Layer Assembly of Hydroxypropyl-

Yudie Jin, Suning Zhang

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Materials Nanoarchitectonics for Advanced Devices.Materials (Basel, Switzerland) · 2024
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yudie JinSchool of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China.ORCID 0009-0000-8861-8224
Suning ZhangSchool of Perfume and Aroma Technology, Shanghai Institute of Technology, Shanghai 201418, China.ORCID 0000-0002-3575-457X

Funding

Shanghai Affiliate Program from Shanghai Promotion Association LM201825
6 · The paper itself

Abstract

Adenosine, as a water-soluble active substance, has various pharmacological effects. This study proposes a layer-by-layer assembly method of composite wall materials, using hydroxypropyl-β-cyclodextrin as the inner wall and whey protein isolate as the outer wall, to encapsulate adenosine within the core material, aiming to enhance adenosine microcapsules' stability through intermolecular interactions. By combining isothermal titration calorimetry with molecular modeling analysis, it was determined that the core material and the inner wall and the inner wall and the outer wall interact through intermolecular forces. Adenosine and hydroxypropyl-β-cyclodextrin form an optimal 1:1 complex through hydrophobic interactions, while hydroxypropyl-β-cyclodextrin and whey protein isolate interact through hydrogen bonds. The embedding rate of AD/Hp-β-CD/WPI microcapsules was 36.80%, and the 24 h retention rate under the release behavior test was 76.09%. The method of preparing adenosine microcapsules using composite wall materials is environmentally friendly and shows broad application prospects in storage and delivery systems with sustained release properties.

Indexed as

2-Hydroxypropyl-beta-cyclodextrinAdenosineCapsulesWhey ProteinsDrug CompoundingDrug LiberationHydrogen BondingHydrophobic and Hydrophilic InteractionsLayer-by-Layer NanoparticlesModels, Molecular2-Hydroxypropyl-beta-cyclodextrinAdenosineCapsulesWhey Proteinsadenosinehydroxypropyl-β-cyclodextrinlayer-by-layer assemblystabilitywhey protein isolate

Identifiers

PMID38731538
PMCPMC11085109

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.