Evidence map›Paper›PMID 38731476›Full record

ArticleMolecules (Basel, Switzerland)2024

Design and Synthesis of Dimethylaminomethyl-Substituted Curcumin Derivatives: Potent Anti-Inflammatory, Anti-Oxidant, and Radioprotection Activity, Improved Aqueous Solubility Compared with Curcumin.

Huiling Gu, Sifan Liu, Kai Liang, Ziming Xia, Guangjie Zhang, Bin Li, Shuchen Liu

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. New 1,2,4-Triazole Derivatives with aInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huiling GuSchool of Pharmacy, Henan University, Kaifeng 475001, China.
Sifan LiuDepartment of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Kai LiangDepartment of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Ziming XiaDepartment of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Guangjie ZhangDepartment of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Bin LiDepartment of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Shuchen LiuDepartment of Pharmaceutical Science, Beijing Institute of Radiation Medicine, Beijing 100850, China.

Funding

National Natural Science Foundation of China 81903497
6 · The paper itself

Abstract

Although the wide variety of bioactivities of curcumin has been reported by researchers, the clinical application of curcumin is still limited due to its poor aqueous solubility. In view of this, a series of dimethylaminomethyl-substituted curcumin derivatives were designed and synthesized (compounds

Indexed as

Anti-Inflammatory AgentsAntioxidantsCurcuminRadiation-Protective AgentsSolubilityAnimalsDrug DesignMiceMolecular StructurePC12 CellsRatsRAW 264.7 CellsStructure-Activity RelationshipWaterAnti-Inflammatory AgentsAntioxidantsCurcuminRadiation-Protective AgentsWateranti-inflammatory activityanti-oxidant activityaqueous solubilitycurcumin derivativesradioprotection activity

Identifiers

PMID38731476
PMCPMC11085442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.