Evidence map›Paper›PMID 38731459›Full record

ReviewMolecules (Basel, Switzerland)2024

Exploring the Biomedical Potential of Terpenoid Alkaloids: Sources, Structures, and Activities.

Xuyan Wang, Jianzeng Xin, Lili Sun, Yupei Sun, Yaxi Xu, Feng Zhao, Changshan Niu, Sheng Liu

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuyan WangSchool of Pharmacy, Yantai University, Yantai 264005, China.
Jianzeng XinSchool of Life Sciences, Yantai University, Yantai 264005, China.
Lili SunCollege of Pharmacy, University of Utah, Salt Lake City, UT 84108, USA.
Yupei SunSchool of Pharmacy, Yantai University, Yantai 264005, China.
Yaxi XuSchool of Pharmacy, Yantai University, Yantai 264005, China.
Feng ZhaoSchool of Pharmacy, Yantai University, Yantai 264005, China.ORCID 0000-0002-9879-6857
Changshan NiuCollege of Pharmacy, University of Utah, Salt Lake City, UT 84108, USA.ORCID 0000-0003-4161-0131
Sheng LiuSchool of Pharmacy, Yantai University, Yantai 264005, China.

Funding

Natural Science Foundation Project of Shandong Province ZR2023QH088Research Start-up Fund for Doctor in Yantai University YX20B03
6 · The paper itself

Abstract

Terpenoid alkaloids are recognized as a class of compounds with limited numbers but potent biological activities, primarily derived from plants, with a minor proportion originating from animals and microorganisms. These alkaloids are synthesized from the same prenyl unit that forms the terpene skeleton, with the nitrogen atom introduced through β-aminoethanol, ethylamine, or methylamine, leading to a range of complex and diverse structures. Based on their skeleton type, they can be categorized into monoterpenes, sesquiterpenes, diterpenes, and triterpene alkaloids. To date, 289 natural terpenoid alkaloids, excluding triterpene alkaloids, have been identified in studies published between 2019 and 2024. These compounds demonstrate a spectrum of biological activities, including anti-inflammatory, antitumor, antibacterial, analgesic, and cardioprotective effects, making them promising candidates for further development. This review provides an overview of the sources, chemical structures, and biological activities of natural terpenoid alkaloids, serving as a reference for future research and applications in this area.

Indexed as

AlkaloidsTerpenesAnimalsAnti-Inflammatory AgentsHumansMolecular StructureAlkaloidsAnti-Inflammatory AgentsTerpenesbiological activitynatural productsterpenoid alkaloids

Identifiers

PMID38731459
PMCPMC11085545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.