Evidence map›Paper›PMID 38730684›Full record

ArticleCancers2024

Debulking Hepatectomy for Colorectal Liver Metastasis Conveys Survival Benefit.

Jennifer A Kalil, Lucyna Krzywon, Oran Zlotnik, Hugo Perrier, Stephanie K Petrillo, Prosanto Chaudhury, Erik Schadde, Peter Metrakos

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jennifer A KalilDepartment of Surgery, Royal Victoria Hospital-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.ORCID 0000-0001-6304-4690
Lucyna KrzywonDepartment of Surgery, Royal Victoria Hospital-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.
Oran ZlotnikDepartment of Surgery, Royal Victoria Hospital-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.ORCID 0000-0002-9965-9432
Hugo PerrierDepartment of Surgery, Royal Victoria Hospital-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.
Stephanie K PetrilloCancer Research Program, Research Institute-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.
Prosanto ChaudhuryDepartment of Surgery, Royal Victoria Hospital-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.ORCID 0000-0002-3461-4620
Erik SchaddeHepatobiliary and Pancreatic Surgery, Surgical Center in Zurich, Surgery Center St. Anna in Lucerne, Beausite Hospital in Berne, Hirslanden Corporation, Witteliker Str. 40, 8032 Zurich, Switzerland.
Peter MetrakosDepartment of Surgery, Royal Victoria Hospital-McGill University Health Center, 1001 Blvd Décarie, Montréal, QC H4A 3J1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: Despite advances in surgical technique and systemic chemotherapy, some patients with multifocal, bilobar colorectal liver metastases (CRLM) remain unresectable. These patients may benefit from surgical debulking of liver tumors in combination with chemotherapy compared to chemotherapy alone. (2) Methods: A retrospective study including patients evaluated for curative intent resection of CRLM was performed. Patients were divided into three groups: those who underwent liver resection with recurrence within 6 months (subtotal debulked, SD), those who had the first stage only of a two-stage hepatectomy (partially debulked, PD), and those never debulked (ND). Kaplan-Meier survival curves and log-rank test were performed to assess the median survival of each group. (3) Results: 174 patients underwent liver resection, and 34 patients recurred within 6 months. Of the patients planned for two-stage hepatectomy, 35 underwent the first stage only. Thirty-two patients were never resected. Median survival of the SD, PD, and ND groups was 31 months, 31 months, and 19.5 months, respectively (

Indexed as

chemotherapycolorectal liver metastasesdebulking hepatectomyliver resectionmedian survival

Identifiers

PMID38730684
PMCPMC11083421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.