ArticleCancers2024
Association between Periodontitis and Hematologic Cancer: An NHIRD Cohort Study in Taiwan.
Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Increased risk of dry eye disease in Taiwanese patients with chronic periodontitis: A nationwide population-based cohort study.Journal of dental sciences · 2026Article
- Long-Term Outcomes of Periodontal Interventions in Children with Leukemia: A Retrospective Analysis.Journal of pharmacy & bioallied sciences · 2025Article
- Use of serum albumin levels and salivary biomarkers in assessing periodontal disease: a community hospital perspective.BMC oral health · 2025Article
- Benefit of nanohydroxyapatite combined with triamcinolone for non-surgical treatment of severe periodontitis: a retrospective study.American journal of translational research · 2025Article
- The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases.International journal of molecular sciences · 2024Review
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Authors and funding
5 authors.
Funding
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Abstract
backgroundChronic periodontitis, an inflammation-related disorder affecting global populations, has been revealed to be linked to diverse cancers. Numerous epidemiological studies have not shown a link between chronic periodontitis and blood cancers in Taiwan.
methodsThis study included 601,628 patients, diagnosed with newly chronic periodontitis by the ICD-9-CM classification, who were enrolled from 2001 to 2021 in the National Health Insurance Research Database (NHIRD) in Taiwan. In this study, we employed comprehensive statistical analyses to investigate the association between chronic periodontitis and hematologic cancers. Initially, we calculated incidence density and used a Poisson regression to analyze relative risk. Subsequently, we compared the cumulative incidence of hematological cancer in both chronic and non-chronic periodontitis groups using the Kaplan-Meier method.
resultsThe results revealed a significantly lower cumulative incidence of hematologic cancer in individuals with non-chronic periodontitis over a 12-year follow-up period. To further explore the risk factors, a Cox proportional hazard regression analysis was conducted. Being male (adjusted hazard ratio [aHR] = 1.21, 95% CI: 1.04 to 1.42;
conclusionsThis study found that being male and having hypertension were the significant risk factors for hematological malignancies. Moreover, the association between chronic periodontitis and specific subtypes of hematologic cancers was confirmed.
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