Evidence map›Paper›PMID 38730607›Full record

ArticleCancers2024

Real-World Treatment Patterns and Survival Outcomes for Patients with Non-Metastatic Non-Small-Cell Lung Cancer in Sweden: A Nationwide Registry Analysis from the I-O Optimise Initiative.

Gudrun N Oskarsdottir, Erik Lampa, Anders Berglund, Linda Rosengren, Maria Ulvestad, Miklos Boros, Melinda J Daumont, Caroline Rault, Gabrielle Emanuel, Cátia Leal and 2 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gudrun N OskarsdottirDepartment of Respiratory Medicine and Allergology, Skåne University Hospital, V/O Hjärt- och Lungmedicin, 222 42 Lund, Sweden.
Erik LampaEpistat AB, 753 30 Uppsala, Sweden.
Anders BerglundEpistat AB, 753 30 Uppsala, Sweden.
Linda RosengrenMedical Department Sweden, Bristol Myers Squibb, Hemvärnsgatan 9, 171 23 Solna, Sweden.
Maria UlvestadMedical Department Nordics, Bristol Myers Squibb, Lysaker Torg 35, 1366 Lysaker, Norway.
Miklos BorosDepartment of Cardiothoracic Surgery, Linköping University Hospital, 581 85 Linköping, Sweden.ORCID 0000-0002-5942-0347
Melinda J DaumontWorldwide Health Economics & Outcomes Research, Bristol Myers Squibb, 1420 Braine-L'Alleud, Belgium.
Caroline RaultData Gnosis, 35200 Rennes, France.
Gabrielle EmanuelReal-World Data Analytics Markets, Bristol Myers Squibb, Uxbridge Business Park, Sanderson Road, Uxbridge UB8 1DH, UK.
Cátia LealIQVIA, 2740-265 Porto Salvo, Portugal.
Minouk J SchoemakerIQVIA, 1101 CT Amsterdam, The Netherlands.
Gunnar WageniusDepartment of Oncology-Pathology, Karolinska Institute, 141 86 Stockholm, Sweden.

Funding

Bristol-Myers Squibb (Belgium) 000
6 · The paper itself

Abstract

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40-50% of patients diagnosed with non-metastatic disease (stages IA-IIIC). The treatment landscape is evolving rapidly as immunotherapies and targeted therapy are introduced in the non-metastatic setting, creating a need to assess patient outcomes prior to their introduction. This real-world study using Swedish National Lung Cancer Registry data examined outcomes (overall survival (OS) and time to next treatment or death (TTNTD)) and treatment patterns for adults diagnosed with non-metastatic NSCLC. Baseline characteristics and OS from diagnosis were described for all patients; OS, treatment patterns, and TTNTD from treatment start were described for the treatment subgroup (patients diagnosed from 2014 onwards), stratified by disease stage and initial treatment. OS and TTNTD were described using the Kaplan-Meier estimator. The overall population (2008-2019) included 17,433 patients; the treatment subgroup included 5147 patients. Median OS (interquartile range) overall ranged from 83.3 (31.6-165.3) months (stage I patients) to 10.4 (4.3-24.2) months (stage IIIB patients). Among the treatment subgroup, median OS and TTNTD were longest among patients receiving surgery versus other anticancer treatments. These findings provide a baseline upon which to evaluate the epidemiology of non-metastatic NSCLC as newer treatments are introduced.

Indexed as

I-O Optimisenon-small-cell lung cancer (NSCLC)overall survivalreal-world evidenceregistrySwedentime to next treatment or death

Identifiers

PMID38730607
PMCPMC11083854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.