Evidence map›Paper›PMID 38730463›Full record

ArticleBMC veterinary research2024

SP2509, a specific antagonist of LSD1, exhibits antiviral properties against Porcine epidemic diarrhea virus.

Xinyu Zhao, Yuhang Zhang, Shiyin Qu, Wuyang Tang, Tianqiong He, Pishun Li, Xiaofeng Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xinyu ZhaoCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Yuhang ZhangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Shiyin QuCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Wuyang TangCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China.
Tianqiong HeDepartment of Laboratory Animal Science, Central South University, Changsha, 410013, China.
Pishun LiCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. lipishun@hunau.edu.cn.
Xiaofeng ZhengCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, 410128, China. zheng.x@hunau.edu.cn.

Funding

Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province and Department of Science and Technology of Hunan Province grants to Pishun Li 2023JJ30291Aid Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province and Department of Science and Technology of Hunan Province grants to Xiaofeng Zheng 2019RS1050 and 2021JJ30354
6 · The paper itself

Abstract

backgroundPorcine epidemic diarrhea virus (PEDV), a type of coronavirus, is one of the main pathogens that can infect pigs of all ages. It causes diarrhea and acute death of newborn piglets, resulting in massive economic losses to the worldwide swine industry. While vaccination remains the primary approach in combating PEDV, it often fails to address all the challenges posed by the infection, particularly in light of the emergence of evolving mutant strains. Therefore, there is a critical need to identify potent antiviral drugs that can effectively safeguard pigs against PEDV infection.

resultsIn this study, the antiviral efficacy of SP2509, a specific antagonist of Lysine-specific demethylase 1(LSD1), was evaluated in vitro. The RT-qPCR, Western blot, TCID

conclusionOur results in vitro show that SP2509 can inhibit PEDV infection during the internalization and replication stage and revealed a role of LSD1 as a restriction factor for PEDV. These imply that LSD1 might be a target for interfering with the viral infection, and SP2509 could be developed as an effective anti-PEDV agent.

Indexed as

Antiviral AgentsHistone DemethylasesPorcine epidemic diarrhea virusVirus ReplicationAnimalsChlorocebus aethiopsCoronavirus InfectionsSwineSwine DiseasesVero CellsAntiviral AgentsHistone DemethylasesAntiviralPorcine epidemic diarrhea virusSP2509

Identifiers

PMID38730463
PMCPMC11084069

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.