SynthesisCritical care (London, England)2024
Incidence, risk factors and outcomes of nosocomial infection in adult patients supported by extracorporeal membrane oxygenation: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Risk factors for nosocomial infections in ECMO patients: a systematic review and meta-analysis.Frontiers in public health · 2026Pooled it
- Hospital-acquired infections in neonatal ECMO patients: a systematic review and meta-analysis.Italian journal of pediatrics · 2025Pooled it
- Do patients receiving extracorporeal membrane-oxygenation need antibiotic prophylaxis? A systematic review and meta-analysis on 7,996 patients.BMC anesthesiology · 2024Pooled it
- Infections following temporary mechanical circulatory support in cardiogenic shock: Incidence, associations, and outcomes.JHLT open · 2026Article
- Host-pathogen interactions during ESKAPE-mediated urinary tract infections and ventilator-associated pneumonia: a review.Folia microbiologica · 2026Review
- Extracorporeal Membrane Oxygenation in Refractory Cardiac Arrest: Current Evidence, Clinical Pathways and Future Directions.Life (Basel, Switzerland) · 2026Review
- Clinical outcomes of VA-ECMO in children with fulminant myocarditis: a single-centre case series.BMC pediatrics · 2026Article
- Epidemiology of nosocomial infections in ECMO patients in Qatar: the CLEAN-Q seven-year retrospective cohort study : CLEAN-Q stands for clinical landscape and epidemiology of acquired nosocomial infections in ECMO patients in Qatar.BMC infectious diseases · 2026Observational
- Invasive Fungal Infections During Extracorporeal Membrane Oxygenation: A Case Series from Intensive Care Unit and Literature Review.Diagnostics (Basel, Switzerland) · 2026Article
- PD-1/TIGIT CD4⁺ T-Cell Signature for Risk Stratification of Post-Weaning Mortality in Venoarterial Extracorporeal Membrane Oxygenation Patients.Journal of inflammation research · 2026Article
- Impact of Plan-Do-Study-Act Cycle-Based Quality Improvement on Head-of-Bed Elevation Compliance, Cuff Pressure Management and Ventilator-Associated Pneumonia in Intensive Care Units: A Before-After Study.Journal of multidisciplinary healthcare · 2026Article
- Infections in mechanical circulatory support.Frontiers in cardiovascular medicine · 2026Review
- Prevention and management of nosocomial infections in patients undergoing extracorporeal membrane oxygenation: a summary of best evidence.Frontiers in medicine · 2026Review
- Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.BMC microbiology · 2025Article
- Japan Intensive Care Consortium: Nationwide Effort for Extracorporeal Membrane Oxygenation Care Optimization and Excellence Study: Study Protocol.Annals of clinical epidemiology · 2025Article
- Sex-specific outcomes in acute myocardial infarction-associated cardiogenic shock treated with and without V-A ECMO: a retrospective German nationwide analysis from 2014 to 2018.Heart and vessels · 2025Article
- Characterization of pathogenic bacterial distribution in extracorporeal membrane oxygenation-related nosocomial infections and the prognostic value of early inflammatory biomarkers for infection survival.Frontiers in microbiology · 2025Article
- ECMO-associated nosocomial infections in adults: immunopathogenesis and predictive modeling approaches.Frontiers in medicine · 2025Review
- Article
- Lack of up-to-date studies and data conversion may lead to biased results: a response to Wang et al.Critical care (London, England) · 2024Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn increasing number of patients requires extracorporeal membrane oxygenation (ECMO) for life support. This supportive modality is associated with nosocomial infections (NIs). This systematic review and meta-analysis aim to assess the incidence and risk factors of NIs in adult.
methodsWe searched PubMed, Scopus, Web of Science, and ProQuest databases up to 2022. The primary endpoint was incidence of NI. Secondary endpoints included time to infection, source of infection, ECMO duration, Intensive care and hospital length of stay (LOS), ECMO survival and overall survival. Incidence of NI was reported as pooled proportions and 95% confidence intervals (CIs), while dichotomous outcomes were presented as risk ratios (RR) as the effective index and 95% CIs using a random-effects model.
resultsAmong the 4,733 adult patients who received ECMO support in the 30 included studies, 1,249 ECMO-related NIs per 1000 ECMO-days was observed. The pooled incidence of NIs across 18 studies involving 3424 patients was 26% (95% CI 14-38%).Ventilator-associated pneumonia (VAP) and bloodstream infections (BSI) were the most common NI sources. Infected patients had lower ECMO survival and overall survival rates compared to non-infected patients, with risk ratio values of 0.84 (95% CI 0.74-0.96, P = 0.01) and 0.80 (95% CI 0.71-0.90, P < 0.001), respectively.
conclusionResults showed that 16% and 20% lower of ECMO survival and overall survival in patients with NI than patients without NI, respectively. However, NI increased the risk of in-hospital mortality by 37% in infected patients compared with non-infected patients. In addition, this study identified the significant positive correlation between ECMO duration and ECMO-related NI.
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