Evidence map›Paper›PMID 38730245›Full record

ArticleNPJ Parkinson's disease2024

Untargeted serum metabolic profiling of diabetes mellitus among Parkinson's disease patients.

Shiwen Li, Yuyuan Lin, Dean Jones, Douglas I Walker, Aline Duarte Folle, Irish Del Rosario, Yu Yu, Keren Zhang, Adrienne M Keener, Jeff Bronstein and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ Parkinson's disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shiwen LiDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8557-2416
Yuyuan LinDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0009-0006-7383-100X
Dean JonesDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, USA.ORCID http://orcid.org/0000-0002-2090-0677
Douglas I WalkerGangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Aline Duarte FolleDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8051-0064
Irish Del RosarioDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Yu YuCenter for Health Policy Research, UCLA Fielding School of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-8717-0245
Keren ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Adrienne M KeenerDepartment of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-1930-6619
Jeff BronsteinDepartment of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA.
Beate RitzDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-6976-7339
Kimberly C PaulDepartment of Neurology, David Geffen School of Medicine, Los Angeles, CA, USA. kimberlp@ucla.edu.ORCID http://orcid.org/0000-0002-4476-2352

Funding

Microbiome, Pesticides and Parkinsons in LatinosR01ES031106 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2020 to 2025
$3.8M
Validation and optimization of epigenetic clocksU01AG060908 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RITZ, BEATE R. · 2018 to 2022
$3.4M
Immune System Aging in Parkinson’s and Alzheimer’s disease: Epigenetics, biologic aging, and heightened immune states in a population-based studyK01AG072044 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAUL, KIMBERLY · 2021 to 2025
$717k
NIA NIH HHS K01 AG072044NIA NIH HHS U01 AG060908NIEHS NIH HHS R01 ES031106
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is a common comorbidity among Parkinson's disease (PD) patients. Yet, little is known about dysregulated pathways that are unique in PD patients with T2DM. We applied high-resolution metabolomic profiling in serum samples of 636 PD and 253 non-PD participants recruited from Central California. We conducted an initial discovery metabolome-wide association and pathway enrichment analysis. After adjusting for multiple testing, in positive (or negative) ion mode, 30 (25) metabolic features were associated with T2DM in both PD and non-PD participants, 162 (108) only in PD participants, and 32 (7) only in non-PD participants. Pathway enrichment analysis identified 17 enriched pathways associated with T2DM in both the PD and non-PD participants, 26 pathways only in PD participants, and 5 pathways only in non-PD participants. Several amino acid, nucleic acids, and fatty acid metabolisms were associated with T2DM only in the PD patient group suggesting a possible link between PD and T2DM.

Identifiers

PMID38730245
PMCPMC11087477

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.