Evidence map›Paper›PMID 38730131›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2024

Vibro-tactile stimulation of the neck reduces pain in people with cervical dystonia: a proof-of-concept study.

Jiapeng Xu, Matteo Costanzo, Laura Avanzino, Davide Martino, Parisa Salehi, Stephanie Standal, Nicoletta Manzo, Parisa Alizadeh, Sara Terranova, Gaia Bonassi and 3 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiapeng Xu *School of Kinesiology, Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, MN, USA.
Matteo Costanzo *Department of Neuroscience, Istituto Superiore Di Sanità, Rome, Italy.
Laura AvanzinoDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Davide MartinoDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Parisa SalehiDepartment of Physical Medicine & Rehabilitation, University of Minnesota, Minneapolis, MN, USA.
Stephanie StandalDepartment of Physical Medicine & Rehabilitation, University of Minnesota, Minneapolis, MN, USA.
Nicoletta ManzoIRCCS San Camillo Hospital, Venice, Italy.
Parisa AlizadehDepartment of Clinical Neurosciences, University of Calgary, Calgary, Canada.
Sara TerranovaDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Gaia BonassiDepartment of Neuroscience, University of Genoa, Genoa, Italy.
Jinseok OhSchool of Kinesiology, Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, MN, USA.
Antonella ConteDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy. antonella.conte@uniroma1.it.ORCID http://orcid.org/0000-0002-6338-2961
Jürgen KonczakSchool of Kinesiology, Human Sensorimotor Control Laboratory, University of Minnesota, Minneapolis, MN, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPain is a common non-motor symptom in patients with cervical dystonia (CD), severely impacting their quality of life. The pathophysiology of CD is incompletely understood but it involves altered processing of proprioceptive and pain signals.

objectivesThe purpose of this proof-of-concept study was to determine if vibro-tactile stimulation (VTS)-a non-invasive form of neuromodulation targeting the somatosensory system-can modulate neck pain in people with CD.

methodsIn a multi-center study, 44 CD patients received VTS to sternocleidomastoid and/or trapezius muscles for up to 45 min under 9 different stimulation conditions that either targeted a single or a pair of muscles. The primary outcome measure was a perceived pain score (PPS) rated by participants on a 100-point analogue scale.

resultsDuring VTS, 29/44 (66%) of participants experienced a reduction in PPS of at least 10% with 17/44 (39%) reporting a reduction in pain of 50% or higher. After VTS cessation, 57% of participants still reported a 10% or higher reduction in PPS. Effects were significant at the group level and persisted for up to 20 min post-treatment. No distinct optimal stimulation profiles were identified for specific CD phenotypes. Clinical markers of disease severity or duration did not predict the degree of VTS-induced pain reduction.

conclusionThis proof-of-concept study demonstrates the potential of VTS as a new non-invasive therapeutic option for treating neck pain associated with CD. Further research needs to delineate optimal dosage and long-term effects.

Indexed as

Neck PainProof of Concept StudyTorticollisVibrationAdultAgedFemaleHumansMaleMiddle AgedNeck MusclesPain MeasurementPhysical StimulationTouchTreatment OutcomeFocal dystoniaHumanPainSomatosensoryVibration

Identifiers

PMID38730131
PMCPMC11422418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.