Evidence map›Paper›PMID 38730109›Full record

ArticleBulletin of experimental biology and medicine2024

Bismuth Nanoparticles Increase Effectiveness of Proton Therapy of Ehrlich Carcinoma.

M V Filimonova, O V Soldatova, A A Shitova, A S Filimonov, V A Rybachuk, A O Kosachenko, K A Nikolaev, G A Demyashkin, A A Popov, I V Zelepukin and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Polyacrylic Acid-Coated LaBPharmaceutics · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

M V FilimonovaA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia. mari_fil@mail.ru.
O V SoldatovaA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
A A ShitovaA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
A S FilimonovA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
V A RybachukA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
A O KosachenkoA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
K A NikolaevA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
G A DemyashkinA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
A A PopovNational Research Nuclear University MEPhI, Moscow, Russia.
I V ZelepukinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
A V KabashinAix-Marseille University, Marseille, France.
S M DeevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
A D KaprinNational Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russia.
P V ShegayA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
S A IvanovA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.
I N ZavestovskayaP. N. Lebedev Physical Institute, Russian Academy of Sciences, Moscow, Russia.
S N KoryakinA. Tsyb Medical Radiological Research Center - Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Obninsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the antitumor activity of the combined use of local proton irradiation in two modes (10 and 31 Gy) with preliminary intra-tumoral injection of two types of bismuth nanoparticles differing in surface coating: coated with the amphiphilic molecule Pluronic-F127 or Silane-PEG (5 kDa)-COOH polymer. Nanoparticles were used in doses of 0.75 and 1.5 mg/mouse. In two independent series on experimental tumor model (solid Ehrlich carcinoma), bismuth nanoparticles of both modifications injected directly into the tumor enhanced the antitumor effects of proton therapy. Moreover, the radiosensitizing effect of bismuth nanoparticles administered via this route increased with the increasing the doses of nanoparticles and the doses of radiation exposure. In our opinion, these promising data obtained for the first time extend the possibilities of treating malignant neoplasms.

Indexed as

BismuthCarcinoma, Ehrlich TumorPoloxamerProton TherapyAnimalsFemaleMetal NanoparticlesMiceNanoparticlesPolyethylene GlycolsRadiation-Sensitizing AgentsBismuthPoloxamerPolyethylene GlycolsRadiation-Sensitizing Agentsantitumor effectivenessnanoparticlesproton irradiationradiosensitizers

Identifiers

PMID38730109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.