Evidence map›Paper›PMID 38730052›Full record

ArticleScientific reports2024

Efficient transplacental transfer of SARS-CoV-2 antibodies between naturally exposed mothers and infants in Accra, Ghana.

Frederica D Partey, Dorotheah Obiri, Evelyn Yayra Bonney, Abigail Naa Adjorkor Pobee, Isaac Kumi Damptey, Keren Ennuson, Jayln Akwetea-Foli, Franklin Yengdem Nuokpem, David Courtin, Kwadwo A Kusi and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Observational
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Frederica D Partey *Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Dorotheah Obiri *Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Evelyn Yayra BonneyDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Abigail Naa Adjorkor PobeeDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Isaac Kumi DampteyDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Keren EnnusonDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Jayln Akwetea-FoliDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Franklin Yengdem NuokpemDepartment of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
David CourtinDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Kwadwo A KusiDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana.
Benedicta A MensahDepartment of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, P.O BOX LG 581, Legon, Accra, Ghana. bmensah@noguchi.ug.edu.gh.

Funding

Noguchi Memorial Institute for Medical Research EC/P26965/01
6 · The paper itself

Abstract

We aimed to determine SARS-CoV-2 antibody seropositivity among pregnant women and the transplacental transfer efficiency of SARS-CoV-2-specific antibodies relative to malaria antibodies among SARS-CoV-2 seropositive mother-cord pairs. This cross-sectional study was conducted in Accra, Ghana, from March to May 2022. Antigen- specific IgG antibodies against SARS-CoV-2 (nucleoprotein and spike-receptor binding domain) and malarial antigens (circumsporozoite protein and merozoite surface protein 3) in maternal and cord plasma were measured by ELISA. Plasma from both vaccinated and unvaccinated pregnant women were tested for neutralizing antibodies using commercial kit. Of the unvaccinated pregnant women tested, 58.12% at antenatal clinics and 55.56% at the delivery wards were seropositive for both SARS-CoV-2 nucleoprotein and RBD antibodies. Anti-SARS-CoV-2 antibodies in cord samples correlated with maternal antibody levels (N antigen r

Indexed as

Antibodies, ViralCOVID-19Immunoglobulin GSARS-CoV-2AdultAntibodies, NeutralizingAntibodies, ProtozoanCross-Sectional StudiesFemaleFetal BloodGhanaHumansImmunity, Maternally-AcquiredInfantInfant, NewbornMaternal-Fetal ExchangeAntibodies, NeutralizingAntibodies, ProtozoanAntibodies, ViralImmunoglobulin GSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19Maternal COVID-19Prenatal COVID-19 placental transferSARS-COV-2Transfer efficiency

Identifiers

PMID38730052
PMCPMC11087586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.