Evidence map›Paper›PMID 38730040›Full record

ArticleBone marrow transplantation2024

Are any specific respiratory viruses more severe than others in recipients of allogeneic stem cell transplantation? A focus on lower respiratory tract disease.

Ariadna Pérez, Dolores Gómez, Juan Montoro, Pedro Chorão, Rafael Hernani, Manuel Guerreiro, Marta Villalba, Eliseo Albert, Juan Antonio Carbonell-Asins, Juan Carlos Hernández-Boluda and 3 more

Abstract read
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In one paragraph

Article in Bone marrow transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ariadna PérezDepartment of Hematology. Hospital Clínico Universitario of Valencia, Spain. INCLIVA Biomedical Research Institute, Valencia, Spain.
Dolores GómezMicrobiology Service, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Juan MontoroHematology Division, Hospital Universitario y Politécnico La Fe, Valencia, Spain.ORCID http://orcid.org/0000-0003-0024-8068
Pedro ChorãoHematology Division, Hospital Universitario y Politécnico La Fe, Valencia, Spain.ORCID http://orcid.org/0000-0001-6741-971X
Rafael HernaniDepartment of Hematology. Hospital Clínico Universitario of Valencia, Spain. INCLIVA Biomedical Research Institute, Valencia, Spain.
Manuel GuerreiroHematology Division, Hospital Universitario y Politécnico La Fe, Valencia, Spain.ORCID http://orcid.org/0000-0001-5978-2578
Marta VillalbaHematology Division, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
Eliseo AlbertMicrobiology Service, Hospital Clínico Universitario, Valencia, Spain.
Juan Antonio Carbonell-AsinsBiostatistics Unit, INCLIVA, Valencia, Spain.
Juan Carlos Hernández-BoludaDepartment of Hematology. Hospital Clínico Universitario of Valencia, Spain. INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID http://orcid.org/0000-0002-4289-3113
David NavarroMicrobiology Service, Hospital Clínico Universitario, Valencia, Spain.ORCID http://orcid.org/0000-0003-3010-4110
Carlos SolanoDepartment of Hematology. Hospital Clínico Universitario of Valencia, Spain. INCLIVA Biomedical Research Institute, Valencia, Spain.ORCID http://orcid.org/0000-0003-3702-0817
José Luis PiñanaDepartment of Hematology. Hospital Clínico Universitario of Valencia, Spain. INCLIVA Biomedical Research Institute, Valencia, Spain. jlpinana@gmail.com.ORCID http://orcid.org/0000-0001-8533-2562

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the general population, influenza virus, respiratory syncytial virus, and SARS-CoV-2 are considered the most severe community-acquired respiratory viruses (CARVs). However, allogeneic stem cell transplant (allo-SCT) recipients may also face severe courses from other CARVs. This retrospective study compared outcomes of various CARV lower respiratory tract diseases (LRTD) in 235 adult allo-SCT recipients, excluding co-infection episodes. We included 235 adults allo-SCT recipients experiencing 353 CARV LRTD consecutive episodes (130 rhinovirus, 63 respiratory syncytial virus, 43 influenza, 43 human parainfluenza virus, 23 human metapneumovirus, 19 Omicron SARS-CoV-2, 17 common coronavirus, 10 adenovirus and 5 human bocavirus) between December 2013 and June 2023. Day 100 overall survival ranged from 78% to 90% without significant differences among CARV types. Multivariable analysis of day 100 all-cause mortality identified corticosteroid use of >1 to <30 mg/d [Hazard ratio (HR) 2.45, p = 0.02) and ≥30 mg/d (HR 2.20, p = 0.015) along with absolute lymphocyte count <0.2 × 10

Indexed as

Respiratory Tract InfectionsAdultAgedCOVID-19FemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedRetrospective StudiesSARS-CoV-2Survival RateTransplantation, HomologousYoung Adult

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.