Evidence map›Paper›PMID 38729987›Full record

ArticleScientific reports2024

Klotho is highly expressed in the chief sites of regulated potassium secretion, and it is stimulated by potassium intake.

Hyun Jun Jung, Truyen D Pham, Xiao-Tong Su, Teodora Veronica Grigore, Joost G Hoenderop, Hannes Olauson, Susan M Wall, David H Ellison, Paul A Welling, Lama Al-Qusairi

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hyun Jun JungDepartment of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Truyen D PhamDepartment of Nephrology, Emory University School of Medicine, Atlanta, GA, USA.
Xiao-Tong SuDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, USA.
Teodora Veronica GrigoreDepartment of Medical BioSciences, Radboud Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.
Joost G HoenderopDepartment of Medical BioSciences, Radboud Research Institute for Medical Innovation, Radboud University Medical Center, Nijmegen, The Netherlands.
Hannes OlausonDivision of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Susan M WallDepartment of Nephrology, Emory University School of Medicine, Atlanta, GA, USA.
David H EllisonDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health and Science University, Portland, USA.
Paul A WellingDepartment of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lama Al-QusairiDepartment of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. lalqusa1@jhmi.edu.

Funding

Molecular of ROMK Channel FunctionR01DK054231 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI Paul A Welling · 1998 to 2026
$7.7M
OXGR1 in Renal Intercalated Cells, Salt Transport and Diuretic EfficacyR01DK110375 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric J Delpire, SUSAN MARIE WALL · 2017 to 2026
$6.7M
Resource Development CoreU54DK137331 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI JOSEF CORESH · 2023 to 2026
$4.3M
Molecular Mechanism of ROMK Channel FunctionR56DK054231 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WELLING, PAUL A · 2022 to 2022
$100k
NIDDK NIH HHS DK054231NIDDK NIH HHS DK110375NIDDK NIH HHS R01 DK054231NIDDK NIH HHS R01 DK110375NIDDK NIH HHS R56 DK054231NIDDK NIH HHS U54 DK137331
6 · The paper itself

Abstract

Klotho regulates many pathways in the aging process, but it remains unclear how it is physiologically regulated. Because Klotho is synthesized, cleaved, and released from the kidney; activates the chief urinary K

Indexed as

AldosteroneGlucuronidaseKlotho ProteinsPotassiumAnimalsFemaleHumansMaleMiceMice, Inbred C57BLMice, KnockoutNephronsPotassium, DietaryReceptors, MineralocorticoidAldosteroneGlucuronidaseKlotho ProteinsKL protein, humanKl protein, mousePotassiumPotassium, DietaryReceptors, Mineralocorticoid

Identifiers

PMID38729987
PMCPMC11087591

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.