Evidence map›Paper›PMID 38729973›Full record

ArticleScientific reports2024

Low-density lipoprotein particle profiles compared with standard lipids measurements in the association with asymptomatic intracranial artery stenosis.

Thien Vu, Yuichiro Yano, Huy Kien Tai Pham, Rajib Mondal, Mizuki Ohashi, Kaori Kitaoka, Mohammad Moniruzzaman, Sayuki Torii, Akihiko Shiino, Atsushi Tsuji and 8 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Thien VuNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Yuichiro YanoNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Huy Kien Tai PhamNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Rajib MondalNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Mizuki OhashiNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Kaori KitaokaNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Mohammad MoniruzzamanNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Sayuki ToriiNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Akihiko ShiinoMolecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Atsushi TsujiDepartment of Neurosurgery, Shiga University of Medical Science, Otsu, Shiga, Japan.
Takashi HisamatsuDepartment of Public Health, Shiga University of Medical Science, Otsu, Shiga, Japan.
Tomonori OkamuraDepartment of Hygiene and Public Health, Keio University School of Medicine, Tokyo, Japan.
Keiko KondoNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Aya KadotaNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Yoshiyuki WatanabeDepartment of Radiology, Shiga University of Medical Science, Otsu, Shiga, Japan.
Kazuhiko NozakiHigashi-Ohmi General Medical Center, Higashiomi, Shiga, Japan.
Hirotsugu UeshimaNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan.
Katsuyuki MiuraNCD Epidemiology Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan. miura@belle.shiga-med.ac.jp.

Funding

Foreign CohortR01HL068200 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SEKIKAWA, AKIRA · 2003 to 2012
$5.6M
Glaxo-Smith Kline GB R01HL068200Ministry of Education, Culture, Sports, Science, and Technology Japan (A) 15H02528Ministry of Education, Culture, Sports, Science, and Technology Japan (A) 17209023Ministry of Education, Culture, Sports, Science, and Technology Japan (A) 18H04074Ministry of Education, Culture, Sports, Science, and Technology Japan (A) 21249043Ministry of Education, Culture, Sports, Science, and Technology Japan (A) 23249036Ministry of Education, Culture, Sports, Science, and Technology Japan (A) 25253046Ministry of Education, Culture, Sports, Science, and Technology Japan (B) 18H03048Ministry of Education, Culture, Sports, Science, and Technology Japan (B) 26293140Ministry of Education, Culture, Sports, Science, and Technology Japan (C) 23590790Ministry of Education, Culture, Sports, Science, and Technology Japan Grants-in-aid for Scientific Research (A) 13307016NHLBI NIH HHS R01 HL068200
6 · The paper itself

Abstract

The Shiga Epidemiological Study of Subclinical Atherosclerosis was conducted in Kusatsu City, Shiga, Japan, from 2006 to 2008. Participants were measured for LDL-p through nuclear magnetic resonance technology. 740 men participated in follow-up and underwent 1.5 T brain magnetic resonance angiography from 2012 to 2015. Participants were categorized as no-ICAS, and ICAS consisted of mild-ICAS (1 to < 50%) and severe-ICAS (≥ 50%) in any of the arteries examined. After exclusion criteria, 711 men left for analysis, we used multiple logistic regression to examine the association between lipid profiles and ICAS prevalence. Among the study participants, 205 individuals (28.8%) had ICAS, while 144 individuals (20.3%) demonstrated discordance between LDL-c and LDL-p levels. The discordance "low LDL-c-high LDL-p" group had the highest ICAS risk with an adjusted OR (95% CI) of 2.78 (1.55-5.00) in the reference of the concordance "low LDL-c-low LDL-p" group. This was followed by the concordance "high LDL-c-high LDL-p" group of 2.56 (1.69-3.85) and the discordance "high LDL-c-low LDL-p" group of 2.40 (1.29-4.46). These findings suggest that evaluating LDL-p levels alongside LDL-c may aid in identifying adults at a higher risk for ICAS.

Indexed as

Lipoproteins, LDLAdultAgedCholesterol, LDLConstriction, PathologicFemaleHumansJapanLipidsMagnetic Resonance AngiographyMaleMiddle AgedRisk FactorsCholesterol, LDLLipidsLipoproteins, LDLIntracranial artery stenosis (ICAS)Low-density lipoprotein cholesterol (LDL-c)Low-density lipoprotein particle (LDL-p)

Identifiers

PMID38729973
PMCPMC11087462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.