Evidence map›Paper›PMID 38729948›Full record

ArticleNature communications2024

TFPI from erythroblasts drives heme production in central macrophages promoting erythropoiesis in polycythemia.

Jun-Kai Ma, Li-Da Su, Lin-Lin Feng, Jing-Lin Li, Li Pan, Qupei Danzeng, Yanwei Li, Tongyao Shang, Xiao-Lin Zhan, Si-Ying Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jun-Kai Ma *Department of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Li-Da Su *Neuroscience Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, 310009, China.ORCID http://orcid.org/0000-0002-3970-5193
Lin-Lin Feng *Department of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Jing-Lin LiDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Li PanThe General Hospital of Tibet Military Area Command, Lhasa, China.
Qupei DanzengDepartment of Tibetan Medicine; University of Tibetan Medicine, Lhasa, 540100, China.
Yanwei LiCore Facilities, Zhejiang University School of Medicine, Hangzhou, China.
Tongyao ShangDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.ORCID http://orcid.org/0000-0002-9821-7085
Xiao-Lin ZhanDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Si-Ying ChenDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China.
Shibo YingSchool of Public Health, Hangzhou Medical College, Hangzhou, 310013, China.ORCID http://orcid.org/0000-0001-5275-9383
Jian-Rao HuSchool of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, Zhejiang, China.
Xue Qun ChenZhejiang University, School of Brain Science and Brain Medicine, Hangzhou, China.ORCID http://orcid.org/0000-0002-6105-8869
Qi ZhangDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. qi.zhang@zju.edu.cn.ORCID http://orcid.org/0000-0002-6096-0690
Tingbo LiangDepartment of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. liangtingbo@zju.edu.cn.ORCID http://orcid.org/0000-0003-0143-3353
Xin-Jiang LuDepartment of Physiology and Department of Hepatobiliary and Pancreatic Surgery of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310058, China. lxj711043@163.com.ORCID http://orcid.org/0000-0002-7796-4401

Funding

National Natural Science Foundation of China (National Science Foundation of China) 41776151National Natural Science Foundation of China (National Science Foundation of China) 81971874Natural Science Foundation of Zhejiang Province (Zhejiang Provincial Natural Science Foundation) LZ23C110001
6 · The paper itself

Abstract

Bleeding and thrombosis are known as common complications of polycythemia for a long time. However, the role of coagulation system in erythropoiesis is unclear. Here, we discover that an anticoagulant protein tissue factor pathway inhibitor (TFPI) plays an essential role in erythropoiesis via the control of heme biosynthesis in central macrophages. TFPI levels are elevated in erythroblasts of human erythroblastic islands with JAK2

Indexed as

ErythroblastsErythropoiesisGATA1 Transcription FactorHemeLipoproteinsMacrophagesPolycythemiaAnimalsFemaleFerrochelataseHumansJanus Kinase 2MaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLFerrochelataseGATA1 protein, humanGATA1 Transcription FactorHemeJAK2 protein, humanJanus Kinase 2lipoprotein-associated coagulation inhibitorLipoproteinsThrombomodulin

Identifiers

PMID38729948
PMCPMC11087540

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.