Evidence map›Paper›PMID 38729162›Full record

ArticleCell chemical biology2024

Behavioral control through the direct, focal silencing of neuronal activity.

Anna V Elleman, Nikola Milicic, Damian J Williams, Jane Simko, Christine J Liu, Allison L Haynes, David E Ehrlich, Christopher D Makinson, J Du Bois

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Saxiphilin is a broad-spectrum toxin sponge for C13-modified saxitoxins.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Impaired axon initial segment structure and function in a model ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Anna V EllemanDepartment of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA 94305, USA.
Nikola MilicicDepartment of Integrative Biology, University of Wisconsin-Madison, 121 Integrative Biology Research Building, 1117 W Johnson St, Madison, WI 53706, USA.
Damian J WilliamsDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, 710 W 168th St, New York, NY 10032, USA.
Jane SimkoDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, 710 W 168th St, New York, NY 10032, USA.
Christine J LiuDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, 710 W 168th St, New York, NY 10032, USA; Department of Neuroscience, Columbia University, Jerome L. Greene Science Center, 3227 Broadway, MC 9872, New York, NY 10027, USA.
Allison L HaynesDepartment of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA 94305, USA.
David E EhrlichDepartment of Integrative Biology, University of Wisconsin-Madison, 121 Integrative Biology Research Building, 1117 W Johnson St, Madison, WI 53706, USA. Electronic address: dehrlich@wisc.edu.
Christopher D MakinsonDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, 710 W 168th St, New York, NY 10032, USA; Department of Neuroscience, Columbia University, Jerome L. Greene Science Center, 3227 Broadway, MC 9872, New York, NY 10027, USA. Electronic address: cm3966@cumc.columbia.edu.
J Du BoisDepartment of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA 94305, USA. Electronic address: jdubois@stanford.edu.

Funding

Guanidinium Toxins as Molecular Probes for NaV StudyR01GM117263 · NIGMS · STANFORD UNIVERSITY · PI DU BOIS, JUSTIN · 2016 to 2024
$3.5M
Unlocking the postnatal human brain using activity augmented organoidsDP2MH132944 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAKINSON, CHRISTOPHER D · 2022 to 2025
$2.4M
Circadian regulation of brain and body in larval zebrafishR35GM146885 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI DAVID Edward EHRLICH · 2022 to 2026
$2.2M
Voltage-gated sodium channel regulation of neocortical developmentR00NS104215 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MAKINSON, CHRISTOPHER DONALD · 2020 to 2022
$744k
Interrogation of voltage gated sodium channel specialization using synthetic saxitoxinR21NS107003 · NINDS · STANFORD UNIVERSITY · PI HUGUENARD, JOHN R · 2018 to 2019
$436k
NIGMS NIH HHS R01 GM117263NIGMS NIH HHS R35 GM146885NIMH NIH HHS DP2 MH132944NINDS NIH HHS R00 NS104215NINDS NIH HHS R21 NS107003
6 · The paper itself

Abstract

The ability to optically stimulate and inhibit neurons has revolutionized neuroscience research. Here, we present a direct, potent, user-friendly chemical approach for optically silencing neurons. We have rendered saxitoxin (STX), a naturally occurring paralytic agent, transiently inert through chemical protection with a previously undisclosed nitrobenzyl-derived photocleavable group. Exposing the caged toxin, STX-bpc, to a brief (5 ms) pulse of light effects rapid release of a potent STX derivative and transient, spatially precise blockade of voltage-gated sodium channels (Na

Indexed as

NeuronsZebrafishAction PotentialsAnimalsBehavior, AnimalHumansLarvaLightMiceSaxitoxinSaxitoxinactional potentialelectrophysiologyphotocagesaxitoxinsodium channelzebrafish

Identifiers

PMID38729162
PMCPMC11260259

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.