ArticleStem cell reports2024
Functional mouse hepatocytes derived from interspecies chimeric livers effectively mitigate chronic liver fibrosis.
Article in Stem cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The making of cells and organs in xenogeneic animal bioreactor.Signal transduction and targeted therapy · 2026Review
- Recent advances in interspecies chimeras and organogenesis.Current opinion in genetics & development · 2025Review
- Characterization of the intraspecies chimeric mouse brain at embryonic day 12.5.Cell transplantationArticle
- An Immunological and Translational Framework for Interspecies Exogenic Liver Transplantation.Cell transplantationReview
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver disease is a major global health challenge. There is a shortage of liver donors worldwide, and hepatocyte transplantation (HT) may be an effective treatment to overcome this problem. However, the present approaches for generation of hepatocytes are associated with challenges, and interspecies chimera-derived hepatocytes produced by interspecies blastocyst complementation (IBC) may be promising donor hepatocytes because of their more comprehensive hepatic functions. In this study, we isolated mouse hepatocytes from mouse-rat chimeric livers using IBC and found that interspecies chimera-derived hepatocytes exhibited mature hepatic functions in terms of lipid accumulation, glycogen storage, and urea synthesis. Meanwhile, they were more similar to endogenous hepatocytes than hepatocytes derived in vitro. Interspecies chimera-derived hepatocytes could relieve chronic liver fibrosis and reside in the injured liver after transplantation. Our results suggest that interspecies chimera-derived hepatocytes are a potentially reliable source of hepatocytes and can be applied as a therapeutic approach for HT.
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Registered trials
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