Evidence map›Paper›PMID 38729109›Full record

ReviewCell2024

The future of rapid and automated single-cell data analysis using reference mapping.

Mohammad Lotfollahi, Yuhan Hao, Fabian J Theis, Rahul Satija

Abstract readReview
In one paragraph

Review in Cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Molecular dynamics of Brodmann Area 22 in development and autism.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. bioRxiv : the preprint server for biology · 2026
    Article
  10. Decoding Alzheimer's Disease One Cell Class at a Time.Cellular and molecular neurobiology · 2026
    Review
  11. CytoVerse: Single-Cell AI Foundation Models in the Browser.bioRxiv : the preprint server for biology · 2026
    Article
  12. Article
  13. Multi-omics dissection of RAD21-PON1 axis reveals metabolic-immune crosstalk and prognostic significance in hepatocellular carcinoma.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Article
  14. Review
  15. Genome biology · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mohammad LotfollahiInstitute of Computational Biology, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK.
Yuhan HaoCenter for Genomics and Systems Biology, New York University, New York, NY, USA; New York Genome Center, New York, NY, USA.
Fabian J TheisInstitute of Computational Biology, Helmholtz Center Munich - German Research Center for Environmental Health, Neuherberg, Germany; Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge, UK; Department of Mathematics, Technical University of Munich, Garching, Germany. Electronic address: fabian.theis@helmholtz-muenchen.de.
Rahul SatijaCenter for Genomics and Systems Biology, New York University, New York, NY, USA; New York Genome Center, New York, NY, USA. Electronic address: rsatija@nygenome.org.

Funding

Center for Integrated Cellular Analysis - Valeria A. Sanchez EstradaRM1HG011014 · NHGRI · NEW YORK GENOME CENTER · PI LANDAU, DAN, SATIJA, RAHUL · 2020 to 2025
$22.1M
Comprehensive reference atlas construction, geolocation and data integration for HuBMAP HIVE [5 of 5]OT2OD033760 · OD · NEW YORK GENOME CENTER · PI SATIJA, RAHUL · 2022 to 2025
$6.1M
Modeling Gene Regulatory Networks for Early Cardiopharyngeal DevelopmentR01HD096770 · NICHD · NEW YORK UNIVERSITY · PI BONNEAU, RICHARD A, CHRISTIAEN, LIONEL · 2018 to 2022
$3.0M
Comprehensive reference map construction, geolocation and data integration for HuBMAP HIVEOT2OD026673 · OD · NEW YORK GENOME CENTER · PI MARIONI, JOHN CARLO, SATIJA, RAHUL · 2018 to 2021
$2.9M
Single-Cell Multi-omics to Link Clonal Mosaicism (CM) Genotypes with Chromatin, Epigenomic, Transcriptomic and Protein PhenotypesUG3NS132139 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LANDAU, DAN, SATIJA, RAHUL · 2023 to 2024
$834k
NHGRI NIH HHS RM1 HG011014NICHD NIH HHS R01 HD096770NIH HHS OT2 OD026673NIH HHS OT2 OD033760NINDS NIH HHS UG3 NS132139
6 · The paper itself

Abstract

As the number of single-cell datasets continues to grow rapidly, workflows that map new data to well-curated reference atlases offer enormous promise for the biological community. In this perspective, we discuss key computational challenges and opportunities for single-cell reference-mapping algorithms. We discuss how mapping algorithms will enable the integration of diverse datasets across disease states, molecular modalities, genetic perturbations, and diverse species and will eventually replace manual and laborious unsupervised clustering pipelines.

Indexed as

AlgorithmsSingle-Cell AnalysisAnimalsCluster AnalysisComputational BiologyData AnalysisHumanscross-species comparisonsmachine learningmultimodal analysisreference mappingsingle-cell analysis

Identifiers

PMID38729109
PMCPMC11184658

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.