ArticlePloS one2024
The PreQuine Platform: A novel diagnostic tool for measuring glucose-6-phosphate dehydrogenase (G6PD) activity and hemoglobin concentration.
Robert Harper, Benedikt Ley, Md Alamgir Kabir, Graham Matulis, Lorenz von Seidlein, Mohammad Shafiul Alam, Bipin Adhikari, Bernard A Okech, Alan L Williams, Ric N Price and 1 more
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In one paragraphArticle in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Robert HarperIn Vitro Diagnostic Solutions, Cherry Hill, New Jersey, United States of America.
Benedikt LeyGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.ORCID 0000-0002-5734-0845 Md Alamgir KabirIn Vitro Diagnostic Solutions, Cherry Hill, New Jersey, United States of America.
Graham MatulisDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida, United States of America.ORCID 0009-0001-4724-1229 Lorenz von SeidleinFaculty of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Mohammad Shafiul AlamInfectious Diseases Division, International Centre for Diarrheal Diseases Research, Bangladesh (icddr,b), Mohakhali, Dhaka, Bangladesh.ORCID 0000-0001-8330-5499 Bipin AdhikariFaculty of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand.
Bernard A OkechDepartment of Preventive Medicine and Biostatistics, F. Edward Herbert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.
Alan L WilliamsDepartment of Family Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America.ORCID 0000-0003-1386-0547 Ric N PriceGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia.
Michael E von FrickenDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida, United States of America.ORCID 0000-0003-2938-4549 Funding
PreQuine Platform. A novel point of care device for the diagnosis andmonitoring of Glucose-6-Phosphate Dehydrogenase (G6PD)SB1AI129057 · NIAID · ANALYTICAL DIAGNOSTIC SOLUTIONS, INC. · PI HARPER, ROBERT · 2021 to 2023
$2.9MA user-friendly point-of-care device for G6PDH determinationR44AI129057 · NIAID · ANALYTICAL DIAGNOSTIC SOLUTIONS, INC. · PI HARPER, ROBERT · 2019 to 2020
$1.4MA user-friendly point-of-care device for G6PDH determinationR43AI129057 · NIAID · ANALYTICAL DIAGNOSTIC SOLUTIONS, INC. · PI HARPER, ROBERT · 2017 to 2017
$191kNIAID NIH HHS R43 AI129057NIAID NIH HHS R44 AI129057NIAID NIH HHS SB1 AI129057Wellcome Trust 200909/Z/16/Z
6 · The paper itselfAbstract
Quantitative diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency is essential for the safe administration of 8-aminoquinoline based radical cure for the treatment of Plasmodium vivax infections. Here, we present the PreQuine Platform (IVDS, USA), a quantitative biosensor that uses a dual-analyte assay for the simultaneous measurement of Hemoglobin (Hgb) levels and G6PD enzyme activity within the same sample. The platform relies on a downloadable mobile application. The device requires 10μl of whole blood and works with a reflectance-based meter. Comparing the G6PD measurement normalized by Hgb of 12 samples from the PreQuine Platform with reference measurements methods (spectrophotometry, Pointe Scientific, USA and hemoglobin meter, HemoCue, Sweden) showed a positive and significant agreement with a slope of 1.0091 and an intercept of -0.0379 under laboratory conditions. Next steps will be to conduct field trials in Bangladesh, Cambodia, and the USA to assess diagnostic performance, user friendliness and acceptance.
Indexed as
Glucosephosphate DehydrogenaseGlucosephosphate Dehydrogenase DeficiencyHemoglobinsAminoquinolinesBiosensing TechniquesHumansMalaria, Vivax8-aminoquinolineAminoquinolinesGlucosephosphate DehydrogenaseHemoglobins
Identifiers
PMID38728310
PMCPMC11086878
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