ArticleDiabetes care2024
Polygenic Risk Score Modifies the Association of HbA1c With Hearing Loss in Middle-Aged and Older Chinese Individuals: The Dongfeng-Tongji Cohort.
Article in Diabetes care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characteristics of Hearing Loss in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Pooled it
- Global trends in hearing loss among the working-age population: a 30-year epidemiological analysis.Annals of medicine · 2026Article
- Hearing Health Monitoring in Adults Living with Diabetes: A Scoping Review to Inform Integrated Care Pathways.Audiology research · 2026Review
- Breadth versus depth: balancing variables, sample size, and quality in Chinese cohort studies.BMJ (Clinical research ed.) · 2025Article
- Burdens of sense organ diseases across global, regional, and national levels from 1990 to 2021 and projections for 2050.BMC public health · 2025Article
- Association of quantified cardiovascular health status with all-cause mortality risk in prediabetic patients.World journal of diabetes · 2025Article
- A biomarker framework for auditory system aging: the Aging Biomarker Consortium consensus statement.Life medicine · 2025Article
- Association between lifestyle behaviors and body mass index with blood pressure classifications among older adults with hypertension in China.Frontiers in public health · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
objectiveEvidence regarding the modifying effect of the polygenic risk score (PRS) on the associations between glycemic traits and hearing loss (HL) was lacking. We aimed to examine whether these associations can be influenced by genetic susceptibility. RESEARCH DESIGN AND
methodsThis cross-sectional study included 13,275 participants aged 64.9 years from the Dongfeng-Tongji cohort. HL was defined according to a pure tone average >25 dB in the better ear and further classified by severity. Prediabetes and type 2 diabetes (T2D) were defined based on the 2013 criteria from the American Diabetes Association. A PRS was derived from 37 single nucleotide polymorphisms associated with HL. Multivariable logistic regression models were fitted to estimate the associations of PRS and glycemic traits with HL and its severity.
resultsElevated fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and T2D were positively associated with higher HL risks and its severity, with odds ratios (ORs) ranging from 1.04 (95% CI 1.00, 1.08) to 1.25 (95% CI 1.06, 1.46). We also found significant interaction between HbA1c and PRS on risks of overall HL and its severity (P for multiplicative interaction <0.05), and the effects of HbA1c on HL risks were significant only in the group with high PRS. Additionally, compared with normoglycemia in the group with low PRS, T2D was associated with an OR of up to 2.00 and 2.40 for overall HL and moderate to severe HL, respectively, in the group with high PRS (P for additive interaction <0.05).
conclusionsPRS modifies the association of HbA1c with HL prevalence among middle-aged and older Chinese individuals.
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