Evidence map›Paper›PMID 38728001›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2024

Transcutaneous Discrimination of Fetal Heart Rate from Maternal Heart Rate: A Fetal Oximetry Proof-of-Concept.

Begum Kasap, Kourosh Vali, Weitai Qian, Lihong Mo, Zahabiya H Chithiwala, Anna C Curtin, Soheil Ghiasi, Herman L Hedriana

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Begum KasapDepartment of Electrical and Computer Engineering, University of California Davis, Davis, CA, USA. bkasap@ucdavis.edu.ORCID 0000-0001-5894-2883
Kourosh ValiDepartment of Electrical and Computer Engineering, University of California Davis, Davis, CA, USA.
Weitai QianDepartment of Electrical and Computer Engineering, University of California Davis, Davis, CA, USA.
Lihong MoDepartment of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA, USA.
Zahabiya H ChithiwalaDepartment of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA, USA.
Anna C CurtinDepartment of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA, USA.
Soheil GhiasiDepartment of Electrical and Computer Engineering, University of California Davis, Davis, CA, USA.
Herman L HedrianaDepartment of Obstetrics and Gynecology, University of California Davis Health, Sacramento, CA, USA.

Funding

UC Davis Clinical and Translational Science CenterUL1TR001860 · NCATS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KENYON, NICHOLAS J., LYLES, COURTNEY REES · 2016 to 2025
$47.3M
TRD3: Data Analytics and Intelligent Systems (AI-ML-DL-Visualization)P41EB032840 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Griffith R. Harsh · 2022 to 2026
$6.7M
Validation of Transabdominal Fetal Pulse Oximetry in Hypoxic Fetal Lamb ModelsR21HD097467 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FARMER, DIANA LEE, GHIASI, SOHEIL · 2020 to 2021
$413k
Division of Information and Intelligent Systems IIS-1838939Eunice Kennedy Shriver National Institute of Child Health and Human Development 5R21HD097467-02NCATS NIH HHS UL1 TR001860NCATS NIH HHS UL1TR001860NIBIB NIH HHS 1P41EB032840NIBIB NIH HHS P41 EB032840NICHD NIH HHS R21 HD097467
6 · The paper itself

Abstract

Intrapartum care uses electronic fetal heart rate monitoring (EFHRM) for over 50 years to indirectly assess fetal oxygenation. However, this approach has been associated with an increase in cesarean delivery rates and limited improvements in neonatal hypoxic outcome. To address these shortcomings, a novel transabdominal fetal pulse oximeter (TFO) is being developed to provide an objective measurement of fetal oxygenation. Previous studies have evaluated the performance of TFO on pregnant ewe. Building on the animal model, this study aims to determine whether TFO can successfully capture human fetal heart rate (FHR) signals during non-stress testing (NST) as a proof-of-concept. Eight ongoing pregnancies meeting specific inclusion criteria (18-40 years old, singleton, and at least 36 weeks' gestation) were enrolled with consent. Each study session was 15 to 20 min long. Reference maternal heart rate (MHR) and FHR were obtained using finger pulse oximetry and cardiotocography for subsequent comparison. The overall root-mean-square error was 9.7BPM for FHR and 4.4 for MHR, while the overall mean-absolute error was 7.6BPM for FHR and 1.8 for MHR. Bland-Altman analysis displayed a mean bias ± standard deviation between TFO and reference of -3.9 ± 8.9BPM, with limits of agreement ranging from -21.4 to 13.6 BPM. Both maternal and fetal heart rate measurements obtained from TFO exhibited a p-value < 0.001, showing significant correlation with the reference. This proof-of-concept study successfully demonstrates that TFO can accurately differentiate maternal and fetal heart signals in human subjects. This achievement marks the initial step towards enabling fetal oxygen saturation measurement in humans using TFO.

Indexed as

Heart RateHeart Rate, FetalOximetryAdolescentAdultCardiotocographyFemaleFetal MonitoringHumansPregnancyProof of Concept StudyYoung AdultFetal heart rate monitoringFetal pulse oximeterFetal well-beingHypoxia/asphyxia

Identifiers

PMID38728001
PMCPMC11932717

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.