Evidence map›Paper›PMID 38727962›Full record

ArticleJapanese journal of radiology2024

Prognostic value of sarcopenia in the patients with locally advanced nasopharyngeal carcinoma.

Ting Liu, Guimei Wang, Chunmei Chen, Lihe He, Rensheng Wang

Abstract read
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Article in Japanese journal of radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Recent Advances in Musculoskeletal Radiology: Bridging Innovation and Clinical Application.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ting LiuDepartment of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Guimei WangDepartment of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Chunmei ChenDepartment of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lihe HeDepartment of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Rensheng WangDepartment of Radiation Oncology, First Affiliated Hospital of Guangxi Medical University, Nanning, China. rs13807806008@163.com.

Funding

National Natural Science Foundation of China 71964003National Natural Science Foundation of China 81460460National Natural Science Foundation of China 81760542National Natural Science Foundation of China 82260467Natural Science Foundation of Guangxi Zhuang Autonomous Region 2018JJA141048
6 · The paper itself

Abstract

purposeSarcopenia, characterized by loss of muscle mass index (SMI), serves as a diagnostic indicator for malnutrition and has been shown to influence cancer treatment outcomes. The objective of this study was to investigate the prognostic significance of sarcopenia on the locally advanced nasopharyngeal carcinoma (laNPC) patients. PATIENTS AND

methods545 patients with stage III-IVa NPC were included in this retrospective study. Sarcopenia was defined using the skeletal muscle index (SMI) determined at the C3 level based on baseline MRI. The log-rank test and the Cox proportional hazards model were used to compare overall survival (OS) and progression-free survival (PFS).

resultsThe results of the multivariate analysis revealed that sarcopenia group (HR = 2.82, 95% CI 1.96-4.06, P < 0.01), T4 stage (HR = 1.64, 95% CI 1.24-2.15, P < 0.01), N3 stage (HR = 1.91, 95% CI 1.52-2.40, P < 0.01), comorbidities (HR = 2.08, 95% CI 1.45-2.97, P < 0.01), and any adverse event grade 3-4 (HR = 1.48, 95% CI 1.04-2.01, P = 0.03) were identified as independent risk factors that significantly impacted the OS. Additionally, sarcopenia group (HR = 2.40, 95% CI 1.73-3.33, P < 0.01), T4 stage (HR = 1.50, 95% CI 1.17-1.92, P < 0.01), N3 stage (HR = 1.80, 95% CI 1.46-2.22, P < 0.01), sarcopenia group (HR = 2.40, 95% CI 1.73-3.33, P < 0.01), and any adverse event grade 3-4 (HR = 1.45, 95% CI 1.04-2.01, P = 0.03) were found to have a significant impact on PFS.

conclusionSarcopenia was identified as a prognostic factor for patients with laNPC. Furthermore, T stage, N stage, comorbidities, and any adverse event grade 3-4 were identified as independent prognostic factors for laNPC.

Indexed as

Magnetic Resonance ImagingNasopharyngeal CarcinomaNasopharyngeal NeoplasmsSarcopeniaAdultAgedFemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesYoung AdultChemoradiotherapyNasopharyngeal carcinomaNomogramPrognosisSarcopenia

Identifiers

PMID38727962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.