Evidence map›Paper›PMID 38727885›Full record

ReviewMedical oncology (Northwood, London, England)2024

Harnessing polyelectrolyte complexes for precision cancer targeting: a comprehensive review.

Bhupendra G Prajapati, Jai Bharti Sharma, Swapnil Sharma, Naitik D Trivedi, Mansi Gaur, Devesh U Kapoor

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bhupendra G PrajapatiShree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva, Gujarat, 384012, India. bhupen27@gmail.com.
Jai Bharti SharmaMM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, Haryana, 133207, India.ORCID http://orcid.org/0000-0003-4509-3688
Swapnil SharmaDepartment of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, 304022, India.ORCID http://orcid.org/0000-0003-2639-7096
Naitik D TrivediAR College of Pharmacy & GH Institute of Pharmacy, VV Nagar, Anand, Gujarat, 388120, India.
Mansi GaurRajasthan Pharmacy College, Rajasthan University of Health Sciences, Jaipur, Rajasthan, 302026, India.ORCID http://orcid.org/0009-0001-9757-6916
Devesh U KapoorDr. Dayaram Patel Pharmacy College, Bardoli, Gujarat, 394601, India. dev7200@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyelectrolytes represent a unique class of polymers abundant in ionizable functional groups. In a solution, ionized polyelectrolytes can intricately bond with oppositely charged counterparts, giving rise to a fascinating phenomenon known as a polyelectrolyte complex. These complexes arise from the interaction between oppositely charged entities, such as polymers, drugs, and combinations thereof. The polyelectrolyte complexes are highly appealing in cancer management, play an indispensable role in chemotherapy, crafting biodegradable, biocompatible 3D membranes, microcapsules, and nano-sized formulations. These versatile complexes are pivotal in designing controlled and targeted release drug delivery systems. The present review emphasizes on classification of polyelectrolyte complex along with their formation mechanisms. This review comprehensively explores the applications of polyelectrolyte complex, highlighting their efficacy in targeted drug delivery strategies for combating different forms of cancer. The innovative use of polyelectrolyte complex presents a potential breakthrough in cancer therapeutics, demonstrating their role in enhancing treatment precision and effectiveness.

Indexed as

Antineoplastic AgentsDrug Delivery SystemsNeoplasmsPolyelectrolytesHumansPrecision MedicineAntineoplastic AgentsPolyelectrolytesCancer therapyLadder-like modelPolyelectrolyte complexTargeted deliveryZeta potential

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.