Evidence map›Paper›PMID 38727822›Full record

ArticleJournal of gastroenterology2024

ALBI score predicts morphological changes in esophageal varices following direct-acting antiviral-induced sustained virological response in patients with liver cirrhosis.

Masanori Atsukawa, Akihito Tsubota, Chisa Kondo, Hidenori Toyoda, Koichi Takaguchi, Makoto Nakamuta, Tsunamasa Watanabe, Asahiro Morishita, Joji Tani, Hironao Okubo and 26 more

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Article in Journal of gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Future of Endoscopy in Surveillance of Esophageal Varices.Current gastroenterology reports · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Masanori Atsukawa *Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, Japan. momogachi@yahoo.co.jp.
Akihito Tsubota *Project Research Units (PRU) Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan.
Chisa KondoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, Japan.
Hidenori ToyodaDepartment of Gastroenterology, Ogaki Municipal Hospital, Gifu, Japan.
Koichi TakaguchiDepartment of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan.
Makoto NakamutaNational Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Tsunamasa WatanabeDepartment of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan.
Asahiro MorishitaDepartment of Gastroenterology, Kagawa University Graduate School of Medicine, Kagawa, Japan.
Joji TaniDepartment of Gastroenterology, Kagawa University Graduate School of Medicine, Kagawa, Japan.
Hironao OkuboDepartment of Gastroenterology, Juntendo Nerima University Hospital, Tokyo, Japan.
Atsushi HiraokaGastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan.
Akito NozakiGastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Makoto ChumaGastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Kazuhito KawataHepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Haruki UojimaDepartment of Gastroenterology, Kitasato University School of Medicine, Kanagawa, Japan.
Chikara OgawaDepartment of Gastroenterology and Hepatology, Takamatsu Red Cross Hospital, Takamatsu, Japan.
Toru AsanoDepartment of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan.
Shigeru MikamiDepartment of Internal Medicine, Division of Gastroenterology, Kikkoman General Hospital, Noda, Japan.
Keizo KatoDivision of Gastroenterology and Hepatology, Shinmatusdo Central General Hospital, Matsudo, Japan.
Kentaro MatsuuraDepartment of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Aichi, Japan.
Tadashi IkegamiDivision of Hepatology and Gastroenterology, Department of Internal Medicine, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Toru IshikawaDepartment of Hepatology, Saiseikai Niigata Hospital, Niigata, Japan.
Kunihiko TsujiCenter for Gastroenterology, Teine Keijinkai Hospital, Sapporo, Japan.
Toshifumi TadaDepartment of Internal Medicine, Japanese Red Cross Himeji Hospital, Hygo, Japan.
Akemi TsutsuiDepartment of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan.
Tomonori SenohDepartment of Hepatology, Kagawa Prefectural Central Hospital, Takamatsu, Japan.
Michika KitamuraDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, Japan.
Tomomi OkuboDepartment of Gastroenterology, Nippon Medical School Chiba Hokusoh Hospital, Inzai, Japan.
Taeang AraiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, Japan.
Motoyuki KohjimaNational Hospital Organization Kyushu Medical Center, Fukuoka, Japan.
Kiyoshi MoritaDepartment of Gastroenterology, Toyota Kosei Hospital, Toyota, Japan.
Takehiro AkahaneDepartment of Gastroenterology, Japanese Red Cross Ishinomaki Hospital, Miyagi, Japan.
Hiroki NishikawaSecond Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Motoh IwasaDepartment of Gastroenterology and Hepatology, Mie University School of Medicine, Mie, Japan.
Yasuhito TanakaDepartment of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Katsuhiko IwakiriDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-Ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to clarify the morphological changes in esophageal varices after achieving sustained virological response (SVR) with direct-acting antivirals (DAAs) in patients with cirrhosis.

methodsA total of 243 patients underwent esophagogastroduodenoscopy before DAA treatment and after achieving SVR. Morphological changes in esophageal varices were investigated using esophagogastroduodenoscopy.

resultsThis study comprised 125 males and 118 females with a median age of 68 years. Esophageal varices at baseline were classified into no varix in 155 (63.8%), F1 in 59 (24.3%), F2 in 25 (10.3%) and F3 in 4 (1.6%) patients. The improvement, unchanged, and aggravation rates of esophageal varices after SVR were 11.9%, 73.3%, and 14.8%, respectively. High ALBI score at SVR12 was an independent factor associated with post-SVR esophageal varices aggravation (p = 0.045). Time-dependent receiver operating characteristic (ROC) curve analysis revealed a cut-off value of - 2.33 for ALBI score at SVR12 in predicting post-SVR esophageal varices aggravation. Of the 155 patients without esophageal varices at baseline, 17 developed de novo post-SVR esophageal varices. High ALBI score at SVR12 was a significant independent factor associated with de novo post-SVR esophageal varices (p = 0.046). ROC curve analysis revealed a cut-off value of - 2.65 for ALBI score at SVR12 in predicting de novo post-SVR esophageal varices.

conclusionsPatients with cirrhosis can experience esophageal varices aggravation or de novo esophageal varices, despite achieving SVR. In particular, patients with high ALBI score at SVR12 have a high likelihood of developing post-SVR esophageal varices aggravation or de novo post-SVR esophageal varices.

Indexed as

Antiviral AgentsEndoscopy, Digestive SystemEsophageal and Gastric VaricesLiver CirrhosisSustained Virologic ResponseAgedAged, 80 and overFemaleHepatitis C, ChronicHumansMaleMiddle AgedRetrospective StudiesROC CurveSeverity of Illness IndexAntiviral AgentsDirect-acting antiviralsEsophageal varicesSustained virological response

Identifiers

PMID38727822

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.