Evidence map›Paper›PMID 38727801›Full record

ArticleHead and neck pathology2024

The Depth of Invasion and Level IV Cervical Node Metastasis in Patients with Clinically N0 Tongue Cancer.

Imdat Yüce, Aslıhan Oflaz Çapar, Veli Çetinaslan, Kemal Deniz, Alperen Vural, Sedat Çağlı, Serap Doğan, Mete Gündoğ

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Article in Head and neck pathology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Imdat YüceDepartment of Otorhinolaryngology Head and Neck Surgery, Erciyes University, Kayseri, Turkey.ORCID http://orcid.org/0000-0003-0938-4437
Aslıhan Oflaz ÇaparDepartment of Otorhinolaryngology Head and Neck Surgery, Erciyes University, Kayseri, Turkey. aslhanoflaz@gmail.com.ORCID http://orcid.org/0000-0003-1056-5753
Veli ÇetinaslanDepartment of Otorhinolaryngology Head and Neck Surgery, Erciyes University, Kayseri, Turkey.
Kemal DenizDepartment of Pathology, Erciyes University, Kayseri, Turkey.
Alperen VuralDepartment of Otorhinolaryngology Head and Neck, Istanbul University - Cerrahpasa, Cerrahpasa Medical Faculty, Istanbul, Turkey.ORCID http://orcid.org/0000-0003-1969-7760
Sedat ÇağlıDepartment of Otorhinolaryngology Head and Neck Surgery, Erciyes University, Kayseri, Turkey.ORCID http://orcid.org/0000-0003-4913-8687
Serap DoğanDepartment of Radiodiagnostics, Erciyes University, Kayseri, Turkey.ORCID http://orcid.org/0000-0001-6331-2245
Mete GündoğDepartment of Radiation Oncology, Erciyes University, Kayseri, Turkey.ORCID http://orcid.org/0000-0001-9195-2442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe accurate indication for level IV dissection is crucial for preventing complications such as phrenic nerve damage and chylous fistulas in clinically N0 tongue cancer. Although the depth of invasion is an established independent risk factor for occult lymph node metastasis in tongue cancer, its relationship with level IV metastasis has not been evaluated. This study investigated the relationship between the depth of invasion and level IV nodal metastasis in clinically N0 tongue cancer.

methodsWe retrospectively investigated clinical N0 patients who underwent glossectomy and level I-IV neck dissection. We examined lymph node metastasis, risk factors, and the relationship between depth of invasion and metastasis.

resultsOur study included 58 patients, and no patient had isolated level IV metastasis. Additionally, there was no level IV metastasis in well-differentiated tumors. Tumor size, depth of invasion, differentiation, and perineural invasion were significantly associated with level IV neck metastasis. We found a critical tumor size of 2.5 cm and depth of invasion of 8 mm for level IV neck metastasis.

conclusionBased on our findings, we recommend that level IV dissection should be considered for poorly differentiated tumors, tumors greater than 2.5 cm in size, and those deeper than 8 mm. This study highlights the importance of depth of invasion as a prognostic factor for predicting level IV metastasis and suggests that our findings can be used to prevent unnecessary level IV dissections that may lead to complications in tongue cancer surgery.

Indexed as

Lymphatic MetastasisNeck DissectionNeoplasm InvasivenessTongue NeoplasmsAdultAgedAged, 80 and overCarcinoma, Squamous CellFemaleGlossectomyHumansMaleMiddle AgedRetrospective StudiesDepth of invasionLevel IV metastasisN0 neckTongue cancer

Identifiers

PMID38727801
PMCPMC11087439

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.