Evidence map›Paper›PMID 38727323›Full record

ArticleCells2024

Floxed

Nopprarat Tongmuang, Kathy Q Cai, Jiahui An, Mariah Novy, Liselotte E Jensen

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. DNA and cell biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nopprarat TongmuangDepartment of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Kathy Q CaiHistopathology Facility, Fox Chase Cancer Center, Temple Health, Philadelphia, PA 19111, USA.
Jiahui AnDepartment of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Mariah NovyDepartment of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.
Liselotte E JensenDepartment of Microbiology, Immunology and Inflammation, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA.ORCID 0000-0002-0267-8312

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
Interleukin-36 cytokines in antiviral immune responsesR01AI125111 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI JENSEN, LISELOTTE E · 2016 to 2020
$2.0M
Dynamic interplay between IL-36 and IL-1 in inflammation and infectionsR01AI178128 · NIAID · TEMPLE UNIV OF THE COMMONWEALTH · PI LISELOTTE E JENSEN · 2023 to 2026
$1.6M
IL-36 activity during skin infectionsR21AR082631 · NIAMS · TEMPLE UNIV OF THE COMMONWEALTH · PI JENSEN, LISELOTTE E · 2023 to 2023
$384k
NCI NIH HHS P30 CA006927NIAID NIH HHS R01 AI125111NIAID NIH HHS R01 AI178128NIAMS NIH HHS R21 AR082631NIH HHS 1R21AR082631-01A1NIH HHS 5R01AI125111-05NIH HHS R01 AI178128
6 · The paper itself

Abstract

IL-36 cytokines are emerging as beneficial in immunity against pathogens and cancers but can also be detrimental when dysregulated in autoimmune and autoinflammatory conditions. Interest in targeting IL-36 activity for therapeutic purposes is rapidly growing, yet many unknowns about the functions of these cytokines remain. Thus, the availability of robust research tools is essential for both fundamental basic science and pre-clinical studies to fully access outcomes of any manipulation of the system. For this purpose, a floxed

Indexed as

Receptors, Interleukin-1AnimalsGene Expression RegulationGenes, ReporterGenetic LociInterleukin-1 Receptor-Like 1 ProteinMiceMice, Inbred C57BLMice, KnockoutRed Fluorescent ProteinIl1rl2 protein, mouseInterleukin-1 Receptor-Like 1 ProteinmCherry fluorescent proteinReceptors, Interleukin-1Red Fluorescent Proteinbarrier tissueepithelial cellsepitheliumIl1rl2IL-1RL2IL-36IL-36RAIL-38interleukinleukocytes

Identifiers

PMID38727323
PMCPMC11083296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.