Evidence map›Paper›PMID 38727010›Full record

ArticleHuman brain mapping2024

Diffusion-tensor-imaging 1-year-old and 2-year-old infant brain atlases with comprehensive gray and white matter labels.

Limei Song, Yun Peng, Minhui Ouyang, Qinmu Peng, Lei Feng, Susan Sotardi, Qinlin Yu, Huiying Kang, Kay L Sindabizera, Shuwei Liu and 1 more

Abstract read
In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Limei SongResearch Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong, China.
Yun PengDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-8213-9716
Minhui OuyangDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8013-2553
Qinmu PengDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Lei FengResearch Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong, China.
Susan SotardiDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Qinlin YuDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Huiying KangDepartment of Radiology, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Kay L SindabizeraDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Shuwei LiuResearch Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong, China.
Hao HuangDepartment of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9103-4382

Funding

A Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell AtlasesUM1MH130991 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hao Huang, ARNOLD KRIEGSTEIN · 2022 to 2026
$25.2M
The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
Structural Development of Human Fetal BrainR01MH092535 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI HUANG, HAO · 2011 to 2020
$4.6M
Infant Atlas of Brain PerfusionR01EB031284 · NIBIB · CHILDREN'S HOSP OF PHILADELPHIA · PI HUANG, HAO · 2021 to 2025
$2.4M
Association of gene expression and brain connectivity in human cerebral cortex development and adulthoodR01MH129981 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HUANG, HAO · 2022 to 2025
$1.8M
Next-generation human connectome atlas across the timespan of brain developmentR01MH125333 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI HUANG, HAO · 2021 to 2022
$456k
Reliable prediction of high-risk infants of autism with cortical microstructural biomarkerR21MH123930 · NIMH · CHILDREN'S HOSP OF PHILADELPHIA · PI OUYANG, MINHUI · 2021 to 2022
$415k
National Institutes of Health (NIH) P50HD105354National Institutes of Health (NIH) R01EB031284National Institutes of Health (NIH) R01MH092535National Institutes of Health (NIH) R01MH125333National Institutes of Health (NIH) R01MH129981National Institutes of Health (NIH) R21MH123930National Institutes of Health (NIH) UM1MH130991Natural Science Foundation of China 31571237Natural Science Foundation of China 81671651Natural Science Foundation of Shandong Province ZR2020QH048NIBIB NIH HHS R01 EB031284NICHD NIH HHS P50 HD105354NIMH NIH HHS R01 MH092535NIMH NIH HHS R01 MH125333NIMH NIH HHS R01 MH129981NIMH NIH HHS R21 MH123930NIMH NIH HHS UM1 MH130991
6 · The paper itself

Abstract

Human infancy is marked by fastest postnatal brain structural changes. It also coincides with the onset of many neurodevelopmental disorders. Atlas-based automated structure labeling has been widely used for analyzing various neuroimaging data. However, the relatively large and nonlinear neuroanatomical differences between infant and adult brains can lead to significant offsets of the labeled structures in infant brains when adult brain atlas is used. Age-specific 1- and 2-year-old brain atlases covering all major gray and white matter (GM and WM) structures with diffusion tensor imaging (DTI) and structural MRI are critical for precision medicine for infant population yet have not been established. In this study, high-quality DTI and structural MRI data were obtained from 50 healthy children to build up three-dimensional age-specific 1- and 2-year-old brain templates and atlases. Age-specific templates include a single-subject template as well as two population-averaged templates from linear and nonlinear transformation, respectively. Each age-specific atlas consists of 124 comprehensively labeled major GM and WM structures, including 52 cerebral cortical, 10 deep GM, 40 WM, and 22 brainstem and cerebellar structures. When combined with appropriate registration methods, the established atlases can be used for highly accurate automatic labeling of any given infant brain MRI. We demonstrated that one can automatically and effectively delineate deep WM microstructural development from 3 to 38 months by using these age-specific atlases. These established 1- and 2-year-old infant brain DTI atlases can advance our understanding of typical brain development and serve as clinical anatomical references for brain disorders during infancy.

Indexed as

Atlases as TopicBrainDiffusion Tensor ImagingGray MatterWhite MatterChild, PreschoolFemaleHumansImage Processing, Computer-AssistedInfantMaleatlasbrain mappingDTIinfant brainparcellationtemplate

Identifiers

PMID38727010
PMCPMC11083905

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.